PMID- 37510157
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 14
DP  - 2023 Jul 19
TI  - Pearls and Pitfalls of Adaptive Optics Ophthalmoscopy in Inherited Retinal 
      Diseases.
LID - 10.3390/diagnostics13142413 [doi]
LID - 2413
AB  - Adaptive optics (AO) retinal imaging enables individual photoreceptors to be 
      visualized in the clinical setting. AO imaging can be a powerful clinical tool 
      for detecting photoreceptor degeneration at a cellular level that might be 
      overlooked through conventional structural assessments, such as spectral-domain 
      optical coherence tomography (SD-OCT). Therefore, AO imaging has gained 
      significant interest in the study of photoreceptor degeneration, one of the most 
      common causes of inherited blindness. Growing evidence supports that AO imaging 
      may be useful for diagnosing early-stage retinal dystrophy before it becomes 
      apparent on fundus examination or conventional retinal imaging. In addition, 
      serial AO imaging may detect structural disease progression in early-stage 
      disease over a shorter period compared to SD-OCT. Although AO imaging is gaining 
      popularity as a structural endpoint in clinical trials, the results should be 
      interpreted with caution due to several pitfalls, including the lack of 
      standardized imaging and image analysis protocols, frequent ocular comorbidities 
      that affect image quality, and significant interindividual variation of normal 
      values. Herein, we summarize the current state-of-the-art AO imaging and review 
      its potential applications, limitations, and pitfalls in patients with inherited 
      retinal diseases.
FAU - Ashourizadeh, Helia
AU  - Ashourizadeh H
AUID- ORCID: 0000-0003-1868-4845
AD  - Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Fakhri, Maryam
AU  - Fakhri M
AD  - Ophthalmic Research Center, Research Institute for Ophthalmology and Vision 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.
FAU - Hassanpour, Kiana
AU  - Hassanpour K
AUID- ORCID: 0000-0002-1788-7352
AD  - Ophthalmic Research Center, Research Institute for Ophthalmology and Vision 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.
FAU - Masoudi, Ali
AU  - Masoudi A
AD  - Stein Eye Institute, David Geffen School of Medicine, University of California, 
      Los Angeles, CA 90095, USA.
FAU - Jalali, Sattar
AU  - Jalali S
AD  - Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran 
      19558, Iran.
FAU - Roshandel, Danial
AU  - Roshandel D
AUID- ORCID: 0000-0002-6716-6406
AD  - Centre for Ophthalmology and Visual Science, The University of Western Australia, 
      Nedlands, WA 6009, Australia.
AD  - Ocular Tissue Engineering Laboratory, Lions Eye Institute, Nedlands, WA 6009, 
      Australia.
FAU - Chen, Fred K
AU  - Chen FK
AUID- ORCID: 0000-0003-2809-9930
AD  - Centre for Ophthalmology and Visual Science, The University of Western Australia, 
      Nedlands, WA 6009, Australia.
AD  - Ocular Tissue Engineering Laboratory, Lions Eye Institute, Nedlands, WA 6009, 
      Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
AD  - Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC 
      3010, Australia.
LA  - eng
GR  - GNT1116360/National Health and Medical Research Council/
GR  - GNT1188694/National Health and Medical Research Council/
GR  - GNT1054712/National Health and Medical Research Council/
GR  - MRF1142962/National Health and Medical Research Council/
PT  - Journal Article
PT  - Review
DEP - 20230719
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10377978
OTO - NOTNLM
OT  - adaptive optics
OT  - inherited retinal disease
OT  - photoreceptor
OT  - retinal dystrophy
OT  - rod-cone dystrophy
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:47
MHDA- 2023/07/29 11:48
PMCR- 2023/07/19
CRDT- 2023/07/29 01:16
PHST- 2023/06/01 00:00 [received]
PHST- 2023/07/12 00:00 [revised]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/07/29 11:48 [medline]
PHST- 2023/07/29 11:47 [pubmed]
PHST- 2023/07/29 01:16 [entrez]
PHST- 2023/07/19 00:00 [pmc-release]
AID - diagnostics13142413 [pii]
AID - diagnostics-13-02413 [pii]
AID - 10.3390/diagnostics13142413 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Jul 19;13(14):2413. doi: 10.3390/diagnostics13142413.