PMID- 37510392
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 7
DP  - 2023 Jul 21
TI  - Tumor Necrosis Factor-alpha G-308A Polymorphism and Sporadic IgA Nephropathy: A 
      Meta-Analysis Using a Genetic Model-Free Approach.
LID - 10.3390/genes14071488 [doi]
LID - 1488
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory cytokine, involved 
      in the pathogenesis and progression of immunoglobulin A nephropathy (IgAN). A 
      bi-allelic polymorphism in the promoter region, at position -308 (G/A) of the 
      TNF-alpha gene (rs1800629) is associated with an increased TNF-a production. However, 
      several previous association studies of TNF-alpha G-308A polymorphism and IgAN 
      rendered contradictory findings. The objective of the present study is to shed 
      light on these inconclusive results and clarify the role of TNF-alpha and any 
      possible contribution of this factor in the development and progression of 
      sporadic IgAN. Therefore, a meta-analysis of all available genetic association 
      studies relating the TNF-alpha G-308A polymorphism to the risk for development and/or 
      progression of IgAN was conducted. Seven studies were included in the 
      meta-analysis. Three of them included populations of European descent 
      (Caucasians) and four involved Asians. The generalized odds ratio (OR(G)) was 
      used to estimate the risk for the development and/or progression of the disease. 
      Overall, the meta-analysis did not detect any significant association between the 
      G-308A variant and both the risk of developing IgAN and the risk for progression 
      of IgAN. In conclusion, these results suggest that TNF-alpha does not constitute a 
      key component in the genetic architecture of sporadic IgAN. However, further 
      evidence deciphering the influence of TNF-alpha on IgAN is still needed.
FAU - Tziastoudi, Maria
AU  - Tziastoudi M
AUID- ORCID: 0000-0002-7206-2716
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larissa, Greece.
FAU - Chronopoulou, Ioanna
AU  - Chronopoulou I
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larissa, Greece.
FAU - Pissas, Georgios
AU  - Pissas G
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larissa, Greece.
FAU - Cholevas, Christos
AU  - Cholevas C
AUID- ORCID: 0000-0002-1517-8691
AD  - First Department of Ophthalmology, Faculty of Health Sciences, Aristotle 
      University of Thessaloniki School of Medicine, AHEPA Hospital, 54636 
      Thessaloniki, Greece.
FAU - Eleftheriadis, Theodoros
AU  - Eleftheriadis T
AUID- ORCID: 0000-0001-9302-1633
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larissa, Greece.
FAU - Stefanidis, Ioannis
AU  - Stefanidis I
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larissa, Greece.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20230721
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (TNF protein, human)
SB  - IM
MH  - Humans
MH  - Genetic Association Studies
MH  - *Glomerulonephritis, IGA/genetics
MH  - Polymorphism, Genetic
MH  - *Tumor Necrosis Factor-alpha/genetics
PMC - PMC10378840
OTO - NOTNLM
OT  - TNF-alpha
OT  - immunoglobulin A nephropathy (IgAN)
OT  - meta-analysis
OT  - polymorphism
OT  - tumor necrosis factor-alpha
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:48
MHDA- 2023/07/31 11:43
PMCR- 2023/07/21
CRDT- 2023/07/29 01:17
PHST- 2023/05/18 00:00 [received]
PHST- 2023/07/11 00:00 [revised]
PHST- 2023/07/19 00:00 [accepted]
PHST- 2023/07/31 11:43 [medline]
PHST- 2023/07/29 11:48 [pubmed]
PHST- 2023/07/29 01:17 [entrez]
PHST- 2023/07/21 00:00 [pmc-release]
AID - genes14071488 [pii]
AID - genes-14-01488 [pii]
AID - 10.3390/genes14071488 [doi]
PST - epublish
SO  - Genes (Basel). 2023 Jul 21;14(7):1488. doi: 10.3390/genes14071488.