PMID- 37510895
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 14
DP  - 2023 Jul 19
TI  - Polymorphisms of Killer Ig-like Receptors and the Risk of Glioblastoma.
LID - 10.3390/jcm12144780 [doi]
LID - 4780
AB  - PURPOSE: The immune responses of natural killer (NK) cells against cancer cells 
      vary by patient. Killer Ig-like receptors (KIRs), which are some of the major 
      receptors involved in regulating NK cell activity for killing cancer cells, have 
      significant genetic variation. Numerous studies have suggested a potential 
      association between the genetic variation of KIR genes and the risk of 
      development or prognosis of various cancer types. However, an association between 
      genetic variations of KIR genes and glioblastoma (GB) remains uncertain. We 
      sought to evaluate the association of genetic variations of KIRs and their ligand 
      genes with the risk of GB development in Koreans. METHODS: A case-control study 
      was performed to identify the odds ratios (ORs) of KIR genes and Classes A, B, 
      and, C of the human leukocyte antigen (HLA) for GB. The GB group was comprised of 
      77 patients with newly diagnosed IDH-wildtype GB at our institution, and the 
      control group consisted of 200 healthy Korean volunteers. RESULTS: There was no 
      significant difference in the frequency of KIR genes and KIR haplotypes between 
      the GB and control groups. Genetic variations of KIR-2DL1, 3DL1, and 3DS1 with 
      their ligand genes (HLA-C2, HLA-Bw4/6, and Bw4, respectively) had effects on the 
      risk of GB in Korean patients. The frequency of KIR-2DL1 with HLA-C2 (OR 2.05, CI 
      1.19-3.52, p = 0.009), the frequency of KIR-3DL1 without HLA-Bw4 (80I) (OR 8.36, 
      CI 4.06-17.18, p < 0.001), and the frequency of KIR-3DL1 with Bw6 (OR 4.54, CI 
      2.55-8.09, p < 0.001) in the GB group were higher than in the control group. In 
      addition, the frequency of KIR-2DL1 without HLA-C2 (OR 0.44, CI 0.26-0.75, p = 
      0.003), the frequency of KIR-3DL1 with HLA-Bw4 (80T) (OR 0.13, CI 0.06-0.27, p < 
      0.001), the frequency of KIR-3DL1 without Bw6 (OR 0.27, CI 0.15-0.49, p < 0.001), 
      and the frequency of KIR-3DS1 with Bw4 (80I) (OR 0.03, CI 0.00-0.50, p < 0.001) 
      in the GB group were lower than in the control group. CONCLUSIONS: This study 
      suggests that genetic variations of KIRs and their ligand genes may affect GB 
      development in the Korean population. Further investigations are needed to 
      demonstrate the different immune responses for GB cells according to genetic 
      variations of KIR genes and their ligand genes.
FAU - Choi, Haeyoun
AU  - Choi H
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul 06591, Republic of Korea.
AD  - Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic 
      University of Korea, Seoul 06591, Republic of Korea.
FAU - Baek, In-Cheol
AU  - Baek IC
AUID- ORCID: 0000-0003-3630-3364
AD  - Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic 
      University of Korea, Seoul 06591, Republic of Korea.
FAU - Park, Soon A
AU  - Park SA
AD  - Department of Biomedicine and Health Sciences, College of Medicine, The Catholic 
      University of Korea, Seoul 06591, Republic of Korea.
FAU - Park, Jae-Sung
AU  - Park JS
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Republic of Korea.
FAU - Jeun, Sin-Soo
AU  - Jeun SS
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Republic of Korea.
FAU - Kim, Tai-Gyu
AU  - Kim TG
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul 06591, Republic of Korea.
AD  - Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic 
      University of Korea, Seoul 06591, Republic of Korea.
FAU - Ahn, Stephen
AU  - Ahn S
AUID- ORCID: 0000-0002-6854-1597
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230719
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10380963
OTO - NOTNLM
OT  - KIR
OT  - Koreans
OT  - glioblastoma
OT  - immunogenetics
OT  - polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:50
MHDA- 2023/07/29 11:51
PMCR- 2023/07/19
CRDT- 2023/07/29 01:20
PHST- 2023/06/10 00:00 [received]
PHST- 2023/07/08 00:00 [revised]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/07/29 11:51 [medline]
PHST- 2023/07/29 11:50 [pubmed]
PHST- 2023/07/29 01:20 [entrez]
PHST- 2023/07/19 00:00 [pmc-release]
AID - jcm12144780 [pii]
AID - jcm-12-04780 [pii]
AID - 10.3390/jcm12144780 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jul 19;12(14):4780. doi: 10.3390/jcm12144780.