PMID- 37510912
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 14
DP  - 2023 Jul 20
TI  - The Role of Right Ventriculo-Arterial Coupling in Symptoms Presentation of 
      Patients with Hypertrophic Cardiomyopathy.
LID - 10.3390/jcm12144796 [doi]
LID - 4796
AB  - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited 
      cardiomyopathy. The hallmark of HCM is myocardial fibrosis which contributes to 
      heart failure, arrhythmias, and sudden cardiac death (SCD). OBJECTIVE: To 
      identify the factors implicated in heart failure symptoms and functional capacity 
      of patients with HCM. METHODS: In this cohort study, 43 patients with HCM were 
      recruited. According to functional capacity and symptoms presentation, patients 
      were categorized according to New York Heart Association (NYHA) classification, 
      and echocardiographic measurements of left ventricle systolic and diastolic 
      function were conducted. The echocardiographic assessment of right 
      ventriculo-arterial coupling (RVAC) was made by calculating the tricuspid annular 
      peak systolic tissue Doppler velocity (TASV)/estimated RV systolic pressure 
      (RVSP) ratio. RESULTS: Almost half (51%) of our study population present symptoms 
      of heart failure and were categorized as the symptomatic group-NYHA 2 or higher. 
      Maximum LVOT gradient, RVSP, and the ratio of E/e' were higher in the symptomatic 
      group compared with the asymptomatic group. TASV was lower in the symptomatic 
      group compared with the asymptomatic group (11 +/- 1 cm/s vs. 13 +/- 2 cm/s, p = 
      0.04). However, there was no difference in other potentially influential factors, 
      such as heart rate or systemic blood pressure. The SCD risk score does not differ 
      between the two studied groups. The RVAC (estimated with the TASV/RVSP ratio) was 
      lower in the symptomatic group compared with the asymptomatic group (0.32 +/- 0.09 
      vs. 0.46 +/- 0.11, p < 0.001). CONCLUSION: A low RVAC (as estimated with TASV/RVSP 
      ratio) value could represent an echocardiographic marker of right 
      ventricular-arterial uncoupling in patients with HCM and impaired functional 
      status.
FAU - Angelopoulos, Andreas
AU  - Angelopoulos A
AUID- ORCID: 0000-0002-5450-3186
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Oikonomou, Evangelos
AU  - Oikonomou E
AUID- ORCID: 0000-0001-8079-0599
AD  - 3rd Department of Cardiology, Sotiria Chest Disease Hospital, Medical School of 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Antonopoulos, Alexios S
AU  - Antonopoulos AS
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Theofilis, Panagiotis
AU  - Theofilis P
AUID- ORCID: 0000-0001-9260-6306
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Kalogeras, Konstantinos
AU  - Kalogeras K
AUID- ORCID: 0000-0003-2036-6192
AD  - 3rd Department of Cardiology, Sotiria Chest Disease Hospital, Medical School of 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Papanikolaou, Paraskevi
AU  - Papanikolaou P
AUID- ORCID: 0000-0001-8348-9216
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Lazaros, George
AU  - Lazaros G
AUID- ORCID: 0000-0003-2802-9617
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Siasos, Gerasimos
AU  - Siasos G
AD  - 3rd Department of Cardiology, Sotiria Chest Disease Hospital, Medical School of 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Tsioufis, Konstantinos
AU  - Tsioufis K
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
FAU - Vlachopoulos, Charalambos
AU  - Vlachopoulos C
AD  - Unit for Inherited and Rare Cardiovascular Diseases, 1st Department of 
      Cardiology, Hippokration Hospital, Medical School of National and Kapodistrian 
      University of Athens, 11527 Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20230720
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10381822
OTO - NOTNLM
OT  - cardiomyopathies
OT  - heart failure
OT  - hypertrophic cardiomyopathy
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:46
MHDA- 2023/07/29 11:47
PMCR- 2023/07/20
CRDT- 2023/07/29 01:20
PHST- 2023/06/10 00:00 [received]
PHST- 2023/07/16 00:00 [revised]
PHST- 2023/07/19 00:00 [accepted]
PHST- 2023/07/29 11:47 [medline]
PHST- 2023/07/29 11:46 [pubmed]
PHST- 2023/07/29 01:20 [entrez]
PHST- 2023/07/20 00:00 [pmc-release]
AID - jcm12144796 [pii]
AID - jcm-12-04796 [pii]
AID - 10.3390/jcm12144796 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jul 20;12(14):4796. doi: 10.3390/jcm12144796.