PMID- 37510957
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 14
DP  - 2023 Jul 22
TI  - Analysis of Peripapillary Retinal Nerve Fiber Layer Thickness in Acute Anterior 
      Uveitis among Children with HLA-B27-Positive Juvenile Idiopathic Arthritis.
LID - 10.3390/jcm12144842 [doi]
LID - 4842
AB  - PURPOSE: The aim of this study was to evaluate changes in the thickness of the 
      peripapillary retinal nerve fiber layer (pRNFL) in children with a diagnosis of 
      juvenile idiopathic arthritis (JIA) who were positive for human leukocyte antigen 
      (HLA)-B27, treated for the first episode of unilateral acute anterior uveitis 
      (AAU). MATERIALS AND METHODS: This retrospective study included 41 children (aged 
      5 to 14 years; mean age 8.32 +/- 2.4 years) with HLA-B27 positivity and unilateral 
      JIA-AAU, and 40 healthy children. Optical coherence tomography (OCT) imaging was 
      performed during active inflammation and subsequent noninflammatory phases (6 
      months after the resolution of inflammatory symptoms in the anterior segment of 
      the eye). RESULTS: There was a marked difference in mean pRNFL thickness between 
      eyes with AU in the active phase, unaffected fellow eyes and the control group 
      (110.22 +/- 5.95 mum, 102.39 +/- 4.39 mum and 95.83 +/- 8.84 mum, respectively; p < 
      0.001). The thickness of pRNFL in eyes with AU in the active phase in all sectors 
      was greater compared to unaffected fellow eyes (p < 0.001) and normal eyes (p < 
      0.001). In addition, it was demonstrated that pRNFL thickness was significantly 
      increased in the superior and temporal sectors in the unaffected fellow eyes 
      compared to the control group (128.73 +/- 13.16 mum vs. 121.48 +/- 13.35 mum and 71.37 
      +/- 4.02 mum vs. 64.98 +/- 9.12 mum, respectively). Even during the inactive phase, 
      eyes with AU, compared to the healthy control group, had significantly greater 
      pRNFL thickness in the inferior sector (129.78 +/- 11.98 mum vs. 122.3 +/- 14.59 mum; p 
      = 0.018), along with the temporal sector (70.88 +/- 5.48 mum vs. 64.98 +/- 9.12 mum; p 
      = 0.001). CONCLUSIONS: An increase in pRNFL thickness in children with unilateral 
      JIA-AAU who were positive for HLA-B27 antigen can be observed in both eyes 
      compared to healthy controls, and this change may persist even after the 
      inflammatory symptoms have resolved. Measurements of pRNFL thickness resulting 
      from JIA-AU-associated glaucoma should be performed during quiescent periods to 
      avoid subclinical changes in pRNFL thickness caused by inflammation. However, 
      when reviewing the results, it should be noted that changes in pRNFL parameters 
      may be present despite evidence of a resolution of inflammation.
FAU - Swierczynska, Marta
AU  - Swierczynska M
AUID- ORCID: 0000-0001-5734-2456
AD  - Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-514 Katowice, Poland.
AD  - Department of Ophthalmology, Kornel Gibinski University Clinical Center, Medical 
      University of Silesia, 40-514 Katowice, Poland.
FAU - Tronina, Agnieszka
AU  - Tronina A
AUID- ORCID: 0000-0002-3651-4017
AD  - Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-514 Katowice, Poland.
AD  - Department of Pediatric Ophthalmology, Kornel Gibinski University Clinical 
      Center, Medical University of Silesia, 40-514 Katowice, Poland.
FAU - Filipek, Erita
AU  - Filipek E
AUID- ORCID: 0000-0002-4227-1349
AD  - Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-514 Katowice, Poland.
AD  - Department of Pediatric Ophthalmology, Kornel Gibinski University Clinical 
      Center, Medical University of Silesia, 40-514 Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20230722
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10381413
OTO - NOTNLM
OT  - HLA-B27
OT  - anterior uveitis
OT  - enthesitis-related arthritis
OT  - juvenile idiopathic arthritis
OT  - pRNFL
OT  - peripapillary retinal nerve fiber layer
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/07/29 11:44
MHDA- 2023/07/29 11:45
PMCR- 2023/07/22
CRDT- 2023/07/29 01:21
PHST- 2023/04/02 00:00 [received]
PHST- 2023/07/12 00:00 [revised]
PHST- 2023/07/21 00:00 [accepted]
PHST- 2023/07/29 11:45 [medline]
PHST- 2023/07/29 11:44 [pubmed]
PHST- 2023/07/29 01:21 [entrez]
PHST- 2023/07/22 00:00 [pmc-release]
AID - jcm12144842 [pii]
AID - jcm-12-04842 [pii]
AID - 10.3390/jcm12144842 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jul 22;12(14):4842. doi: 10.3390/jcm12144842.