PMID- 37510962
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 14
DP  - 2023 Jul 23
TI  - Investigating Adiposity-Related Metabolic Health Phenotypes in Patients with 
      Hidradenitis Suppurativa: A Cross-Sectional Study.
LID - 10.3390/jcm12144847 [doi]
LID - 4847
AB  - BACKGROUND: Obesity and hidradenitis suppurativa (HS) are related through 
      meta-inflammation and are both associated with increased cardiometabolic risk. 
      Notwithstanding, cardiometabolic pathology is not uniform in obesity and a subset 
      of individuals with excess adiposity exhibit a healthy metabolic profile. Whilst 
      the incidence of cardiometabolic endpoints and transitions across different 
      adiposity-related body composition phenotypes within several populations and 
      across different ethnicities have been investigated, data regarding metabolic 
      health (MetH) and body composition phenotypes in individuals with HS are lacking. 
      The objective of this study was to evaluate the relationship between different 
      body composition phenotypes in individuals with HS. METHODS: This was a 
      cross-sectional study of 632 individuals with and without HS from a population 
      with a high prevalence of both obesity and HS. A total of four body composition 
      phenotypes were generated based on BMI and metabolic status (defined using either 
      the metabolic syndrome definition or the homeostasis model of insulin resistance 
      (HOMA-IR)): metabolically healthy overweight/obese (MHOWOB), metabolically 
      unhealthy overweight/obese (MUOWOB), metabolically healthy normal weight (MHNW), 
      and metabolically unhealthy normal weight (MUNW). RESULTS: Generally, subjects 
      with HS exhibited a worse metabolic profile with higher levels of indices of 
      central adiposity measures (including Visceral Adiposity Index and waist 
      circumference), systolic blood pressure and markers of insulin resistance, as 
      well as a higher prevalence of the metabolic syndrome. Moreover, when 
      sub-stratified into the different body composition phenotypes, individuals with 
      HS typically also demonstrated adverse metabolic characteristics relative to 
      controls matched for both adiposity and metabolic health, particularly in the 
      normal weight category and despite being classified as metabolically healthy. 
      Being metabolically unhealthy in addition to being overweight/obese increases an 
      individual's risk of HS. CONCLUSIONS: Metabolic risk-assessment should be 
      prioritized in the clinical management of individuals with HS even in those who 
      are lean. Patients attending HS clinics provide a valuable opportunity for 
      targeted cardiovascular risk reduction with respect to the management of both 
      obesity and metabolic health.
FAU - Mintoff, Dillon
AU  - Mintoff D
AUID- ORCID: 0000-0003-3705-0119
AD  - Department of Pathology, Faculty of Medicine and Surgery, University of Malta, 
      MSD2080 Msida, Malta.
AD  - Department of Dermatology, Mater Dei Hospital, MSD2090 Msida, Malta.
FAU - Agius, Rachel
AU  - Agius R
AUID- ORCID: 0000-0002-4547-6008
AD  - Department of Medicine, Faculty of Medicine and Surgery, University of Malta, 
      MSD2080 Msida, Malta.
AD  - Department of Medicine, Mater Dei Hospital, MSD2090 Msida, Malta.
FAU - Fava, Stephen
AU  - Fava S
AD  - Department of Medicine, Faculty of Medicine and Surgery, University of Malta, 
      MSD2080 Msida, Malta.
AD  - Department of Medicine, Mater Dei Hospital, MSD2090 Msida, Malta.
FAU - Pace, Nikolai P
AU  - Pace NP
AUID- ORCID: 0000-0002-7332-874X
AD  - Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, 
      MSD2080 Msida, Malta.
AD  - Centre for Molecular Medicine and Biobanking, University of Malta, MSD2080 Msida, 
      Malta.
LA  - eng
GR  - Tertiary Educational Scholarship Scheme/Government of Malta/
GR  - Institutional funds/University of Malta/
PT  - Journal Article
DEP - 20230723
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10381271
OTO - NOTNLM
OT  - hidradenitis suppurativa
OT  - metabolic health
OT  - obesity
OT  - phenotypes
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:49
MHDA- 2023/07/29 11:50
PMCR- 2023/07/23
CRDT- 2023/07/29 01:21
PHST- 2023/07/07 00:00 [received]
PHST- 2023/07/20 00:00 [revised]
PHST- 2023/07/22 00:00 [accepted]
PHST- 2023/07/29 11:50 [medline]
PHST- 2023/07/29 11:49 [pubmed]
PHST- 2023/07/29 01:21 [entrez]
PHST- 2023/07/23 00:00 [pmc-release]
AID - jcm12144847 [pii]
AID - jcm-12-04847 [pii]
AID - 10.3390/jcm12144847 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jul 23;12(14):4847. doi: 10.3390/jcm12144847.