PMID- 37511071
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 14
DP  - 2023 Jul 11
TI  - Revealing a Third Dissolved-Phase Xenon-129 Resonance in Blood Caused by 
      Hemoglobin Glycation.
LID - 10.3390/ijms241411311 [doi]
LID - 11311
AB  - Hyperpolarized (HP) xenon-129 ((129)Xe), when dissolved in blood, has two NMR 
      resonances: one in red blood cells (RBC) and one in plasma. The impact of 
      numerous blood components on these resonances, however, has not yet been 
      investigated. This study evaluates the effects of elevated glucose levels on the 
      chemical shift (CS) and T2* relaxation times of HP (129)Xe dissolved in sterile 
      citrated sheep blood for the first time. HP (129)Xe was mixed with sheep blood 
      samples premixed with a stock glucose solution using a liquid-gas exchange 
      module. Magnetic resonance spectroscopy was performed on a 3T clinical MRI 
      scanner using a custom-built quadrature dual-tuned (129)Xe/(1)H coil. We observed 
      an additional resonance for the RBCs ((129)Xe-RBC1) for the increased glucose 
      levels. The CS of (129)Xe-RBC1 and (129)Xe-plasma peaks did not change with 
      glucose levels, while the CS of (129)Xe-RBC2 (original RBC resonance) increased 
      linearly at a rate of 0.015 +/- 0.002 ppm/mM with glucose level. (129)Xe-RBC1 T2* 
      values increased nonlinearly from 1.58 +/- 0.24 ms to 2.67 +/- 0.40 ms. As a result 
      of the increased glucose levels in blood samples, the novel additional HP (129)Xe 
      dissolved phase resonance was observed in blood and attributed to the (129)Xe 
      bound to glycated hemoglobin (HbA(1c)).
FAU - Mikowska, Lutoslawa
AU  - Mikowska L
AUID- ORCID: 0000-0001-9416-445X
AD  - Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian 
      University, 30-348 Krakow, Poland.
FAU - Grynko, Vira
AU  - Grynko V
AUID- ORCID: 0000-0002-9580-0072
AD  - Chemistry and Material Science Program, Lakehead University, Thunder Bay, ON P7B 
      5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, Thunder Bay, ON P7B 7A5, Canada.
FAU - Shepelytskyi, Yurii
AU  - Shepelytskyi Y
AUID- ORCID: 0000-0001-5526-7958
AD  - Thunder Bay Regional Health Research Institute, Thunder Bay, ON P7B 7A5, Canada.
AD  - Chemistry Department, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.
FAU - Ruset, Iullian C
AU  - Ruset IC
AD  - Xemed LLC, Durham, NH 03824, USA.
FAU - Deschamps, Joseph
AU  - Deschamps J
AD  - Applied Life Sciences Program, Lakehead University, Thunder Bay, ON P7B 5E1, 
      Canada.
FAU - Aalto, Hannah
AU  - Aalto H
AD  - Applied Life Sciences Program, Lakehead University, Thunder Bay, ON P7B 5E1, 
      Canada.
FAU - Targosz-Korecka, Marta
AU  - Targosz-Korecka M
AD  - Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian 
      University, 30-348 Krakow, Poland.
FAU - Balamore, Dilip
AU  - Balamore D
AD  - Department of Engineering, Physics and Technology, Nassau Community College, New 
      York, NY 11530, USA.
FAU - Haranczyk, Hubert
AU  - Haranczyk H
AD  - Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian 
      University, 30-348 Krakow, Poland.
FAU - Albert, Mitchell S
AU  - Albert MS
AD  - Thunder Bay Regional Health Research Institute, Thunder Bay, ON P7B 7A5, Canada.
AD  - Chemistry Department, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.
AD  - Faculty of Medical Sciences, Northern Ontario School of Medicine University, 
      Thunder Bay, ON P3E 2C6, Canada.
LA  - eng
PT  - Journal Article
DEP - 20230711
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Xenon-129)
RN  - 0 (Xenon Isotopes)
RN  - 0 (Hemoglobins)
RN  - IY9XDZ35W2 (Glucose)
RN  - 3H3U766W84 (Xenon)
SB  - IM
MH  - Animals
MH  - Sheep
MH  - *Maillard Reaction
MH  - *Xenon Isotopes/chemistry
MH  - Magnetic Resonance Imaging/methods
MH  - Hemoglobins
MH  - Glucose
MH  - Xenon
MH  - Lung
PMC - PMC10380088
OTO - NOTNLM
OT  - glucose
OT  - glycation
OT  - hemoglobin
OT  - hyperpolarized 129Xe
OT  - magnetic resonance spectroscopy
COIS- Author I.C.R. was employed by the company Xemed LLC, Durham, NH, USA. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/29 11:54
MHDA- 2023/07/31 06:42
PMCR- 2023/07/11
CRDT- 2023/07/29 01:21
PHST- 2023/05/27 00:00 [received]
PHST- 2023/07/06 00:00 [revised]
PHST- 2023/07/10 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/07/29 11:54 [pubmed]
PHST- 2023/07/29 01:21 [entrez]
PHST- 2023/07/11 00:00 [pmc-release]
AID - ijms241411311 [pii]
AID - ijms-24-11311 [pii]
AID - 10.3390/ijms241411311 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jul 11;24(14):11311. doi: 10.3390/ijms241411311.