PMID- 37511742
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 13
IP  - 7
DP  - 2023 Jul 12
TI  - Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients 
      with Head and Neck Cancer Receiving Chemoradiotherapy.
LID - 10.3390/jpm13071129 [doi]
LID - 1129
AB  - Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and 
      neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous 
      electrical sensory stimulation (TESS), developed in recent years for swallowing 
      rehabilitation, is used at many medical facilities. Although TESS has been used 
      for dysphagia in several fields, its safety and efficacy in patients with head 
      and neck cancer remain to be clarified. Therefore, this study evaluated the 
      safety of TESS in ten patients with head and neck cancers undergoing CRT. 
      Swallowing rehabilitation intervention and TESS implementation were performed for 
      all patients during CRT. Non-blood-toxicity adverse events (AEs), such as 
      dermatitis and mucositis, occurred during CRT; however, the severity was less 
      than grade 3. No patient experienced pain due to TESS. As survival time analysis 
      using the Kaplan-Meier method for interferential current device implementation 
      rates revealed a feasibility of 100% for up to 60 Gy and a feasibility of 78% for 
      up to 70 Gy, TESS may be feasible until 70 Gy. This study confirmed the 
      feasibility and safety of TESS in the head and neck region during CRT. Although 
      the precise mechanism of TESS on dysphagia remains unclear, its continued use has 
      great potential for improving sensory disturbance.
FAU - Hamamoto, Takao
AU  - Hamamoto T
AUID- ORCID: 0000-0001-9728-1264
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Sato, Yuki
AU  - Sato Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Yumii, Kohei
AU  - Yumii K
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Chikuie, Nobuyuki
AU  - Chikuie N
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Taruya, Takayuki
AU  - Taruya T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Horibe, Yuichiro
AU  - Horibe Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Ishino, Takashi
AU  - Ishino T
AUID- ORCID: 0000-0002-0646-0839
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Ueda, Tsutomu
AU  - Ueda T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Takeno, Sachio
AU  - Takeno S
AUID- ORCID: 0000-0002-9853-2501
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University 
      Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Yoshimura, Kenichi
AU  - Yoshimura K
AD  - Medical Center for Translational and Clinical Research, Hiroshima University 
      Hospital, Hiroshima 734-8555, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230712
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC10381452
OTO - NOTNLM
OT  - chemoradiotherapy
OT  - dysphagia
OT  - electric stimulation
OT  - head and neck neoplasms
OT  - swallowing
COIS- The Food Care Corporation provided the consumables used for attaching the IFCDs. 
      Conflicts related to this study were properly managed using standards for the 
      management of Conflicts of Interest in Clinical Research under the Clinical 
      Research Act. The funders had no role in the design of the study; in the 
      collection, analyses, or interpretation of data; in the writing of the 
      manuscript; or in the decision to publish the results.
EDAT- 2023/07/29 11:44
MHDA- 2023/07/29 11:45
PMCR- 2023/07/12
CRDT- 2023/07/29 01:26
PHST- 2023/05/31 00:00 [received]
PHST- 2023/07/07 00:00 [revised]
PHST- 2023/07/09 00:00 [accepted]
PHST- 2023/07/29 11:45 [medline]
PHST- 2023/07/29 11:44 [pubmed]
PHST- 2023/07/29 01:26 [entrez]
PHST- 2023/07/12 00:00 [pmc-release]
AID - jpm13071129 [pii]
AID - jpm-13-01129 [pii]
AID - 10.3390/jpm13071129 [doi]
PST - epublish
SO  - J Pers Med. 2023 Jul 12;13(7):1129. doi: 10.3390/jpm13071129.