PMID- 37512021
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 7
DP  - 2023 Jun 27
TI  - Double Malignancy and Double Transplant-A Bumpy Road to Success.
LID - 10.3390/medicina59071209 [doi]
LID - 1209
AB  - The occurrence of secondary neoplasms in adult patients treated with chemotherapy 
      in childhood is not uncommon. Prior chemotherapy is found to be an independent 
      risk factor for the development of secondary malignancies, which are usually 
      associated with a worse prognosis. The presented case is a 35-year-old female 
      patient who was diagnosed with Ewing sarcoma in her late adolescence. The tumor 
      was successfully treated with chemotherapy, but 3 years later she was diagnosed 
      with T-cell lymphoblastic lymphoma. The patient received allogeneic hematopoietic 
      stem cell transplantation (allo-HSCT) from human leukocyte antigen (HLA) matched 
      related donor. The procedure was complicated by grade 2 acute graft-versus-host 
      disease (GvHD) which resolved after implementation of immunosuppressive 
      treatment. However, a year later, the patient developed extensive chronic GvHD 
      (cGvHD) and required reintroduction of immunosuppressants. Prolonged 
      immunosuppressive treatment with tacrolimus led to irreversible kidney failure. 
      After a 2-year period of regular peritoneal dialysis, she was found to be 
      eligible for a kidney transplant from a deceased donor. Now, 15 years after stem 
      cell transplantation and 8 years after kidney transplantation, the patient 
      remains in good condition overall, presenting with symptoms of limited cGvHD. The 
      case described here presents a unique clinical scenario of a female patient who 
      was successfully treated for her double malignancy. Moreover, she underwent 
      effective double transplantations and was eventually found to be cured despite 
      accompanying complications.
FAU - Razik, Michal
AU  - Razik M
AD  - Students' Research Group, Department of Hematology and Bone Marrow 
      Transplantation, Faculty of Medicine in Katowice, Medical University of Silesia, 
      40-055 Katowice, Poland.
FAU - Rozwadowska, Patrycja
AU  - Rozwadowska P
AUID- ORCID: 0000-0001-8541-2108
AD  - Students' Research Group, Department of Hematology and Bone Marrow 
      Transplantation, Faculty of Medicine in Katowice, Medical University of Silesia, 
      40-055 Katowice, Poland.
FAU - Koclega, Anna
AU  - Koclega A
AD  - Department of Hematology and Bone Marrow Transplantation, Faculty of Medicine in 
      Katowice, Medical University of Silesia, 40-055 Katowice, Poland.
FAU - Helbig, Grzegorz
AU  - Helbig G
AD  - Department of Hematology and Bone Marrow Transplantation, Faculty of Medicine in 
      Katowice, Medical University of Silesia, 40-055 Katowice, Poland.
LA  - eng
PT  - Case Reports
DEP - 20230627
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Adolescent
MH  - Female
MH  - Transplantation, Homologous/adverse effects
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - *Graft vs Host Disease/drug therapy/etiology
MH  - Immunosuppressive Agents/therapeutic use
MH  - *Neoplasms/complications
PMC - PMC10384397
OTO - NOTNLM
OT  - Ewing sarcoma
OT  - T-cell lymphoblastic lymphoma
OT  - allogeneic stem cell transplantation
OT  - complications
OT  - immunosuppressive treatment
OT  - kidney transplantation
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:52
MHDA- 2023/07/31 06:43
PMCR- 2023/06/27
CRDT- 2023/07/29 01:27
PHST- 2023/05/15 00:00 [received]
PHST- 2023/06/24 00:00 [revised]
PHST- 2023/06/26 00:00 [accepted]
PHST- 2023/07/31 06:43 [medline]
PHST- 2023/07/29 11:52 [pubmed]
PHST- 2023/07/29 01:27 [entrez]
PHST- 2023/06/27 00:00 [pmc-release]
AID - medicina59071209 [pii]
AID - medicina-59-01209 [pii]
AID - 10.3390/medicina59071209 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Jun 27;59(7):1209. doi: 10.3390/medicina59071209.