PMID- 37513453
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 14
DP  - 2023 Jul 22
TI  - pH-Responsive Cobalt(II)-Coordinated Assembly Containing Quercetin for 
      Antimicrobial Applications.
LID - 10.3390/molecules28145581 [doi]
LID - 5581
AB  - The development of novel drug delivery systems (DDSs) with promising 
      antibacterial properties is essential for facing the emergency of increasing 
      resistance to antimicrobial agents. The antibacterial features of quercetin and 
      its metal complexes have been broadly investigated. However, several drawbacks 
      affect their activity and effectiveness. In this work, we propose a DDS based on 
      a pH-responsive cobalt(II)-coordinated assembly containing quercetin and 
      polyacrylic acid. This system is suggested to trigger the release of the model 
      drug in a pH-dependent mode by exploiting the localized acidic environment at the 
      bacterial infection sites under anaerobic conditions. The delivery system has 
      been designed by accurately examining the species and the multiple equilibria 
      occurring in solution among the assembly components. The formation of cobalt(II) 
      complexes with quercetin in the absence or presence of the pH-responsive 
      polyacrylic acid was investigated in buffered aqueous solution at pH 7.4 using 
      spectrophotometric (UV-Vis) and calorimetric (ITC) techniques. The determined 
      binding affinities and thermodynamic parameters that resulted are essential for 
      the development of a DDS with improved binding and release capabilities. 
      Furthermore, the affinity of the polymer-cobalt(II) complex toward the model 
      antimicrobial flavonoid was explored at the solid-liquid interface by quartz 
      crystal microbalance (QCM-D) experiments, which provided marked evidence for drug 
      loading and release under pH control.
FAU - Santonoceta, Giuseppina D G
AU  - Santonoceta GDG
AD  - Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, 
      95125 Catania, Italy.
FAU - Sgarlata, Carmelo
AU  - Sgarlata C
AUID- ORCID: 0000-0002-9284-1303
AD  - Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, 
      95125 Catania, Italy.
LA  - eng
GR  - PRIN 2015MP34H3/Ministry of Education, Universities and Research/
GR  - Piaceri 2020-22, linea 2/University of Catania/
PT  - Journal Article
DEP - 20230722
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 9IKM0I5T1E (Quercetin)
RN  - 3G0H8C9362 (Cobalt)
RN  - 0 (Coordination Complexes)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - *Quercetin/pharmacology
MH  - Cobalt/chemistry
MH  - *Coordination Complexes/pharmacology/chemistry
MH  - Anti-Bacterial Agents/pharmacology/chemistry
MH  - Hydrogen-Ion Concentration
PMC - PMC10386366
OTO - NOTNLM
OT  - Co(II) complexes
OT  - ITC calorimetry
OT  - QCM-D
OT  - antimicrobial agents
OT  - drug delivery
OT  - pH-responsive systems
OT  - quercetin
OT  - solid-liquid interface
OT  - solution equilibria and thermodynamics
OT  - speciation
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:47
MHDA- 2023/07/31 06:42
PMCR- 2023/07/22
CRDT- 2023/07/29 01:35
PHST- 2023/06/28 00:00 [received]
PHST- 2023/07/17 00:00 [revised]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/07/29 11:47 [pubmed]
PHST- 2023/07/29 01:35 [entrez]
PHST- 2023/07/22 00:00 [pmc-release]
AID - molecules28145581 [pii]
AID - molecules-28-05581 [pii]
AID - 10.3390/molecules28145581 [doi]
PST - epublish
SO  - Molecules. 2023 Jul 22;28(14):5581. doi: 10.3390/molecules28145581.