PMID- 37513723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 12
IP  - 7
DP  - 2023 Jun 26
TI  - Detection of Coronaviruses in Bats in Lebanon during 2020.
LID - 10.3390/pathogens12070876 [doi]
LID - 876
AB  - Bats are considered the main reservoir of coronaviruses (CoVs), and research 
      evidence suggests the essential role of bats in the emergence of Severe Acute 
      Respiratory Syndrome Coronaviruses (SARS-CoV) and SARS-CoV-2. SARS-CoV-like 
      viruses have been recently detected in bats in different countries. In 2020, we 
      conducted surveillance for CoVs among six different bat species in Lebanon. Of 
      622 swab specimens taken, 77 tested positive. Alpha- and Beta- CoVs were 
      identified in samples collected from different species. Our results show that 
      SARS-like coronaviruses circulate in bats in this region, and we provide new data 
      on their genetic diversity. The interaction between the spike of the detected 
      SARS-CoV-like viruses and the human angiotensin-converting enzyme 2 (hACE2) 
      receptor could be crucial in understanding the origin of the epidemic. The 3D 
      protein structure analysis revealed that the receptor-binding domains of the 
      SARS-like virus identified in Lebanon bind to the hACE2 protein more efficiently 
      than to the spike of the SARS-CoV-2 strain. The spike of the detected 
      SARS-CoV-like viruses does not contain the recognition site of furin at the 
      cleavage site. Thus, our study highlights the variety of bat coronaviruses in 
      Lebanon and suggests the zoonotic potential for other SARS-CoV-like viruses.
FAU - Kandeil, Ahmed
AU  - Kandeil A
AUID- ORCID: 0000-0003-3253-6961
AD  - Department of Infectious Diseases, St. Jude Children's Research Hospital, 
      Memphis, TN 38105, USA.
AD  - Center of Scientific Excellence for Influenza Virus, Institute of Environmental 
      Research and Climate Change, National Research Centre, Giza 12622, Egypt.
AD  - Human Link DMCC, Dubai 115738, United Arab Emirates.
FAU - Abi-Said, Mounir
AU  - Abi-Said M
AD  - L2GE Department of Earth and Life Sciences, Faculty of Sciences II, Lebanese 
      University, Fanar 90656, Lebanon.
FAU - Badra, Rebecca
AU  - Badra R
AUID- ORCID: 0000-0002-3482-6965
AD  - Human Link DMCC, Dubai 115738, United Arab Emirates.
FAU - El-Shesheny, Rabeh
AU  - El-Shesheny R
AUID- ORCID: 0000-0002-8798-2240
AD  - Center of Scientific Excellence for Influenza Virus, Institute of Environmental 
      Research and Climate Change, National Research Centre, Giza 12622, Egypt.
AD  - Human Link DMCC, Dubai 115738, United Arab Emirates.
FAU - Al-Karmalawy, Ahmed A
AU  - Al-Karmalawy AA
AUID- ORCID: 0000-0002-8173-6073
AD  - Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian 
      University, Giza 12566, Egypt.
FAU - Alnajjar, Radwan
AU  - Alnajjar R
AUID- ORCID: 0000-0003-1869-9596
AD  - Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi 
      1308, Libya.
AD  - Faculty of Pharmacy, Libyan International Medical University, Benghazi 16063, 
      Libya.
FAU - Khalid, Zumama
AU  - Khalid Z
AD  - Department of Health Sciences, University of Genova, 16126 Genova, Italy.
FAU - Kamel, Mina Nabil
AU  - Kamel MN
AD  - Center of Scientific Excellence for Influenza Virus, Institute of Environmental 
      Research and Climate Change, National Research Centre, Giza 12622, Egypt.
FAU - Abi Habib, Walid
AU  - Abi Habib W
AUID- ORCID: 0000-0001-7017-7854
AD  - Multi-Omics Laboratory, School of Pharmacy, Lebanese American University, P.O. 
      Box 36, Byblos 1401, Lebanon.
FAU - Abdallah, Jad
AU  - Abdallah J
AUID- ORCID: 0000-0001-5267-4953
AD  - Multi-Omics Laboratory, School of Pharmacy, Lebanese American University, P.O. 
      Box 36, Byblos 1401, Lebanon.
FAU - Dhanasekaran, Vijaykrishna
AU  - Dhanasekaran V
AUID- ORCID: 0000-0003-3293-6279
AD  - School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, 
      Hong Kong 999077, China.
AD  - HKU-Pasteur Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 
      999077, China.
FAU - Webby, Richard
AU  - Webby R
AUID- ORCID: 0000-0002-4397-7132
AD  - Department of Infectious Diseases, St. Jude Children's Research Hospital, 
      Memphis, TN 38105, USA.
FAU - Kayali, Ghazi
AU  - Kayali G
AD  - Human Link DMCC, Dubai 115738, United Arab Emirates.
LA  - eng
GR  - HHSN272201400006C/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20230626
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC10383746
OTO - NOTNLM
OT  - Lebanon
OT  - SARS-CoV-2
OT  - bat
OT  - coronaviruses
OT  - reservoir
OT  - zoonoses
COIS- The authors declare no conflicts of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/07/29 11:46
MHDA- 2023/07/29 11:47
PMCR- 2023/06/26
CRDT- 2023/07/29 01:37
PHST- 2023/05/24 00:00 [received]
PHST- 2023/06/23 00:00 [revised]
PHST- 2023/06/23 00:00 [accepted]
PHST- 2023/07/29 11:47 [medline]
PHST- 2023/07/29 11:46 [pubmed]
PHST- 2023/07/29 01:37 [entrez]
PHST- 2023/06/26 00:00 [pmc-release]
AID - pathogens12070876 [pii]
AID - pathogens-12-00876 [pii]
AID - 10.3390/pathogens12070876 [doi]
PST - epublish
SO  - Pathogens. 2023 Jun 26;12(7):876. doi: 10.3390/pathogens12070876.