PMID- 37514050
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 15
IP  - 7
DP  - 2023 Jul 1
TI  - Innovative Strategies for Drug Delivery to the Ocular Posterior Segment.
LID - 10.3390/pharmaceutics15071862 [doi]
LID - 1862
AB  - Innovative and new drug delivery systems (DDSs) have recently been developed to 
      vehicle treatments and drugs to the ocular posterior segment and the retina. New 
      formulations and technological developments, such as nanotechnology, novel 
      matrices, and non-traditional treatment strategies, open new perspectives in this 
      field. The aim of this mini-review is to highlight promising strategies reported 
      in the current literature based on innovative routes to overcome the anatomical 
      and physiological barriers of the vitreoretinal structures. The paper also 
      describes the challenges in finding appropriate and pertinent treatments that 
      provide safety and efficacy and the problems related to patient compliance, 
      acceptability, effectiveness, and sustained drug delivery. The clinical 
      application of these experimental approaches can help pave the way for 
      standardizing the use of DDSs in developing enhanced treatment strategies and 
      personalized therapeutic options for ocular pathologies.
FAU - Gabai, Andrea
AU  - Gabai A
AUID- ORCID: 0000-0002-3865-3336
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Zeppieri, Marco
AU  - Zeppieri M
AUID- ORCID: 0000-0003-0999-5545
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Finocchio, Lucia
AU  - Finocchio L
AUID- ORCID: 0000-0003-1986-045X
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
AD  - Department of Ophthalmology, Nuovo Ospedale Santo Stefano, 59100 Prato, Italy.
FAU - Salati, Carlo
AU  - Salati C
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230701
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC10385847
OTO - NOTNLM
OT  - drug delivery systems (DDSs)
OT  - matrices
OT  - nanotechnology
OT  - ocular posterior segment
OT  - vitreoretinal
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:51
MHDA- 2023/07/29 11:52
PMCR- 2023/07/01
CRDT- 2023/07/29 01:39
PHST- 2023/05/18 00:00 [received]
PHST- 2023/06/19 00:00 [revised]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/07/29 11:52 [medline]
PHST- 2023/07/29 11:51 [pubmed]
PHST- 2023/07/29 01:39 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - pharmaceutics15071862 [pii]
AID - pharmaceutics-15-01862 [pii]
AID - 10.3390/pharmaceutics15071862 [doi]
PST - epublish
SO  - Pharmaceutics. 2023 Jul 1;15(7):1862. doi: 10.3390/pharmaceutics15071862.