PMID- 37515402
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20231005
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 24
IP  - 10
DP  - 2023 Oct
TI  - Microvascular complications of obesity and diabetes-Role of bariatric surgery.
PG  - e13602
LID - 10.1111/obr.13602 [doi]
AB  - Bariatric surgery in people with obesity can lead to long-term remission of type 
      2 diabetes mellitus (T2DM) and a reduction in the incidence of macrovascular 
      complications. The impact of bariatric surgery on microvascular complications is 
      less clear. In this narrative review, we sought to evaluate the effect of 
      bariatric surgery on microvascular complications in patients with and without 
      diabetes. The risk of developing microvascular complications is increased in 
      people with obesity, and this is amplified in those with T2DM. The impact of 
      metabolic surgery on microvascular complications is limited to a subgroup 
      analysis of studies or statistical modeling to predict the glycemia-independent 
      effect of bariatric surgery. While bariatric surgery halts the progression of 
      retinopathy in those with minimal retinopathy, it may worsen in those with 
      advanced retinopathy. Bariatric surgery improves proteinuria and major renal 
      outcomes, regardless of the severity of renal impairment. Bariatric surgery in 
      patients with obesity with or without diabetes is associated with an improvement 
      in neuropathic symptoms and regeneration of small nerve fibers. In conclusion, 
      bariatric surgery is associated with an improvement in microvascular 
      complications. Further studies are needed to elucidate the underlying mechanisms 
      for the favorable effect of bariatric surgery on microvascular outcomes.
CI  - (c) 2023 World Obesity Federation.
FAU - Bashir, Bilal
AU  - Bashir B
AUID- ORCID: 0000-0003-3733-8331
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Centre for Diabetes, Endocrinology and Metabolism, Manchester University NHS 
      Foundation Trust, Manchester, UK.
FAU - Iqbal, Zohaib
AU  - Iqbal Z
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Centre for Diabetes, Endocrinology and Metabolism, Manchester University NHS 
      Foundation Trust, Manchester, UK.
FAU - Adam, Safwaan
AU  - Adam S
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK.
FAU - Ferdousi, Maryam
AU  - Ferdousi M
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
FAU - Chick, William
AU  - Chick W
AUID- ORCID: 0000-0002-9342-2274
AD  - Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK.
FAU - Hussein, Heleen A
AU  - Hussein HA
AD  - College of Medicine, Hawler Medical University, Erbil, Iraq.
FAU - Syed, Akheel A
AU  - Syed AA
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Department of Endocrinology, Diabetes and Obesity Medicine, Salford Royal 
      Hospital NHS Foundation Trust, Salford, UK.
FAU - Le Roux, Carel W
AU  - Le Roux CW
AD  - Diabetes Complications Research Centre, School of Medicine, Conway Institute of 
      Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
FAU - Cohen, Ricardo V
AU  - Cohen RV
AUID- ORCID: 0000-0001-8779-3055
AD  - The Centre for Obesity and Diabetes, Oswaldo Cruz German Hospital, Sao Paulo, 
      Brazil.
FAU - Malik, Rayaz A
AU  - Malik RA
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.
FAU - Soran, Handrean
AU  - Soran H
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK.
AD  - Centre for Diabetes, Endocrinology and Metabolism, Manchester University NHS 
      Foundation Trust, Manchester, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230729
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the 
      Study of Obesity
JID - 100897395
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Obesity/complications
MH  - *Bariatric Surgery/adverse effects
MH  - *Retinal Diseases/complications
MH  - Postoperative Complications/etiology
OTO - NOTNLM
OT  - bariatric surgery
OT  - metabolic syndrome
OT  - microvascular complications
OT  - obesity
EDAT- 2023/07/29 11:46
MHDA- 2023/09/07 06:43
CRDT- 2023/07/29 03:15
PHST- 2023/05/19 00:00 [revised]
PHST- 2022/11/07 00:00 [received]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/09/07 06:43 [medline]
PHST- 2023/07/29 11:46 [pubmed]
PHST- 2023/07/29 03:15 [entrez]
AID - 10.1111/obr.13602 [doi]
PST - ppublish
SO  - Obes Rev. 2023 Oct;24(10):e13602. doi: 10.1111/obr.13602. Epub 2023 Jul 29.