PMID- 37517058
OWN - NLM
STAT- MEDLINE
DCOM- 20230801
LR  - 20240515
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Print)
IS  - 0002-0729 (Linking)
VI  - 52
IP  - 7
DP  - 2023 Jul 1
TI  - Exploring the natural history of intrinsic capacity impairments: longitudinal 
      patterns in the 10/66 study.
LID - 10.1093/ageing/afad137 [doi]
LID - afad137
AB  - BACKGROUND: intrinsic capacity (IC) is a construct encompassing people's physical 
      and mental abilities. There is an implicit link amongst IC domains: cognition, 
      locomotion, nutrition, sensory and psychological. However, little is known about 
      the integration of the domains. OBJECTIVES: to investigate patterns in the 
      presentation and evolution of IC domain impairments in low-and-middle-income 
      countries and if such patterns were associated with adverse outcomes. METHODS: 
      secondary analyses of the first two waves of the 10/66 study (population-based 
      surveys conducted in eight urban and four rural catchment areas in Cuba, 
      Dominican Republic, Puerto Rico, Venezuela, Peru, Mexico and China). We applied 
      latent transition analysis on IC to find latent statuses (latent clusters) of IC 
      domain impairments. We evaluated the longitudinal association of the latent 
      statuses with the risk of frailty, disability and mortality, and tested 
      concurrent and predictive validity. RESULTS: amongst 14,923 participants 
      included, the four latent statuses were: high IC (43%), low deterioration with 
      impaired locomotion (17%), high deterioration without cognitive impairment (22%), 
      and high deterioration with cognitive impairment (18%). A total of 61% of the 
      participants worsened over time, 35% were stable, and 3% improved to a healthier 
      status.Participants with deteriorated IC had a significantly higher risk of 
      frailty, disability and dementia than people with high IC. There was strong 
      concurrent and predictive validity. (Mortality Hazard Ratio = 4.60, 95%CI 4.16; 
      5.09; Harrel's C = 0.73 (95%CI 0.72;0.74)). CONCLUSIONS: half of the study 
      population had high IC at baseline, and most participants followed a worsening 
      trend. Four qualitatively different IC statuses or statuses were characterised by 
      low and high levels of deterioration associated with their risk of disability and 
      frailty. Locomotion and cognition impairments showed other trends than 
      psychological and nutrition domains across the latent statuses.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      British Geriatrics Society.
FAU - Gonzalez-Bautista, Emmanuel
AU  - Gonzalez-Bautista E
AUID- ORCID: 0000-0001-9844-3034
AD  - Maintain Aging Research Team, CERPOP, Universite de Toulouse, Inserm, Universite 
      Paul Sabatier, Toulouse, France.
AD  - Institute on Aging, Toulouse University Hospital (CHU), Gerontopole, Toulouse, 
      France.
AD  - Department of Health Service & Population Research, King's College London, 
      Institute of Psychiatry, Psychology &Neuroscience, London, UK.
FAU - Llibre-Guerra, Jorge Jesus
AU  - Llibre-Guerra JJ
AUID- ORCID: 0000-0002-2137-7750
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Sosa, Ana L
AU  - Sosa AL
AD  - National Institute of Neurology and Neurosurgery of Mexico, National Autonomous 
      University of Mexico, Mexico City, Mexico.
FAU - Acosta, Isaac
AU  - Acosta I
AD  - Internal Medicine Department, Geriatric Section, Universidad Nacional Pedro 
      Henriquez Urena, Santo Domingo, Dominican Republic.
FAU - Andrieu, Sandrine
AU  - Andrieu S
AD  - Maintain Aging Research Team, CERPOP, Universite de Toulouse, Inserm, Universite 
      Paul Sabatier, Toulouse, France.
FAU - Acosta, Daisy
AU  - Acosta D
AD  - Internal Medicine Department, Geriatric Section, Universidad Nacional Pedro 
      Henriquez Urena, Santo Domingo, Dominican Republic.
FAU - Llibre-Rodriguez, Juan de Jesus
AU  - Llibre-Rodriguez JJ
AD  - Facultad de Medicina Finlay-Albarran, Medical University of Havana, Havana, Cuba.
FAU - Prina, Matthew
AU  - Prina M
AUID- ORCID: 0000-0001-6698-3263
AD  - Department of Health Service & Population Research, King's College London, 
      Institute of Psychiatry, Psychology &Neuroscience, London, UK.
AD  - Faculty of Medical Sciences, Population Health Sciences Institute, Newcastle 
      University, Newcastle Upon Tyne, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - K01 AG073526/AG/NIA NIH HHS/United States
GR  - GR066133/WT_/Wellcome Trust/United Kingdom
GR  - GR08002/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
MH  - Humans
MH  - *Frailty/diagnosis/epidemiology
MH  - Mexico/epidemiology
MH  - Cuba/epidemiology
MH  - Dominican Republic/epidemiology
MH  - Health Status
PMC - PMC10387229
OTO - NOTNLM
OT  - intrinsic capacity
OT  - latent transitions
OT  - longitudinal analysis
OT  - natural history of functional decline
OT  - older people
COIS- None.
EDAT- 2023/07/30 19:11
MHDA- 2023/08/01 06:45
PMCR- 2023/07/29
CRDT- 2023/07/30 14:51
PHST- 2022/12/18 00:00 [received]
PHST- 2023/08/01 06:45 [medline]
PHST- 2023/07/30 19:11 [pubmed]
PHST- 2023/07/30 14:51 [entrez]
PHST- 2023/07/29 00:00 [pmc-release]
AID - 7232308 [pii]
AID - afad137 [pii]
AID - 10.1093/ageing/afad137 [doi]
PST - ppublish
SO  - Age Ageing. 2023 Jul 1;52(7):afad137. doi: 10.1093/ageing/afad137.