PMID- 37518066 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230802 IS - 1757-4749 (Print) IS - 1757-4749 (Electronic) IS - 1757-4749 (Linking) VI - 15 IP - 1 DP - 2023 Jul 31 TI - A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study. PG - 38 LID - 10.1186/s13099-023-00556-x [doi] LID - 38 AB - BACKGROUND: The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori (H. pylori) infection, as compared with conventional outpatient education (OE). METHODS: We randomized 254 H. pylori-positive patients into a DTD group (127 patients) and an OE group (127 patients) prior to primary treatment with 14-day bismuth-containing quadruple therapy, including esomeprazole, amoxicillin, and clarithromycin. Both groups received consistent medication instructions. Patients in the DTD group recorded daily attendance after completing their daily medication plan from day 1 to day 14. The medication compliance, follow-up compliance, H. pylori eradication rates, and adverse events (AEs) were evaluated. RESULTS: In the modified intention-to-treat (MITT) and per-protocol (PP) analyses, the DTD group showed significantly higher medication compliance than the OE group (P = 0.001 and P = 0.031, respectively). Both the MITT and PP analyses showed significant differences in follow-up compliance (P < 0.001 and P = 0.003, respectively) and timing of the review urea breath test (P < 0.001 and P = 0.001, respectively) between the two groups. However, no significant differences were observed in the H. pylori eradication rates (95.8% vs. 93.8%, P = 0.529) in the PP analysis, or AEs incidence (25.4% vs. 28.3%, P = 0.603) between the two groups. CONCLUSION: This study demonstrated the novel application of the DTD model in the treatment of H. pylori infection, which enabled patients to develop habitual medication-taking behaviors without physician intervention. CI - (c) 2023. The Author(s). FAU - Yang, Zhen AU - Yang Z AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Xiong, Wenjie AU - Xiong W AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Yang, Ruoyun AU - Yang R AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Qian, Haisheng AU - Qian H AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - He, Zhi AU - He Z AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Chen, Meihong AU - Chen M AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Yang, Jiajia AU - Yang J AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Sang, Huaiming AU - Sang H AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Yan, Jin AU - Yan J AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Xu, Xiaobing AU - Xu X AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Wang, Yun AU - Wang Y AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. FAU - Zhang, Guoxin AU - Zhang G AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. guoxinz@njmu.edu.cn. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. guoxinz@njmu.edu.cn. FAU - Ye, Feng AU - Ye F AD - Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. fengye@njmu.edu.cn. AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. fengye@njmu.edu.cn. LA - eng GR - 81970499/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81970499/National Natural Science Foundation of China/ GR - 81970499/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 81970499/National Natural Science Foundation of China/ GR - 81500431/National Natural Science Foundation of China/ GR - 2018-WSW-003/Six Talent Peaks Project in Jiangsu Province/ GR - 2018-WSW-003/Six Talent Peaks Project in Jiangsu Province/ GR - S2021-1/Social Science and Technology Development Project of Nanjing Pukou District/ PT - Journal Article DEP - 20230731 PL - England TA - Gut Pathog JT - Gut pathogens JID - 101474263 PMC - PMC10388557 OTO - NOTNLM OT - Compliance OT - Conventional outpatient education OT - Day-to-day OT - Habit formation OT - Helicobacter pylori infection COIS- The authors declare no competing interests. EDAT- 2023/07/31 00:41 MHDA- 2023/07/31 00:42 PMCR- 2023/07/31 CRDT- 2023/07/30 23:33 PHST- 2023/04/21 00:00 [received] PHST- 2023/06/06 00:00 [accepted] PHST- 2023/07/31 00:42 [medline] PHST- 2023/07/31 00:41 [pubmed] PHST- 2023/07/30 23:33 [entrez] PHST- 2023/07/31 00:00 [pmc-release] AID - 10.1186/s13099-023-00556-x [pii] AID - 556 [pii] AID - 10.1186/s13099-023-00556-x [doi] PST - epublish SO - Gut Pathog. 2023 Jul 31;15(1):38. doi: 10.1186/s13099-023-00556-x.