PMID- 37520521
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Transcriptional regulation of dendritic cell development and function.
PG  - 1182553
LID - 10.3389/fimmu.2023.1182553 [doi]
LID - 1182553
AB  - Dendritic cells (DCs) are sentinel immune cells that form a critical bridge 
      linking the innate and adaptive immune systems. Extensive research addressing the 
      cellular origin and heterogeneity of the DC network has revealed the essential 
      role played by the spatiotemporal activity of key transcription factors. In 
      response to environmental signals DC mature but it is only following the sensing 
      of environmental signals that DC can induce an antigen specific T cell response. 
      Thus, whilst the coordinate action of transcription factors governs DC 
      differentiation, sensing of environmental signals by DC is instrumental in 
      shaping their functional properties. In this review, we provide an overview that 
      focuses on recent advances in understanding the transcriptional networks that 
      regulate the development of the reported DC subsets, shedding light on the 
      function of different DC subsets. Specifically, we discuss the emerging knowledge 
      on the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC 
      subset, DC3. Additionally, we examine critical transcription factors such as 
      IRF8, PU.1, and E2-2 and their regulatory mechanisms and downstream targets. We 
      highlight the complex interplay between these transcription factors, which shape 
      the DC transcriptome and influence their function in response to environmental 
      stimuli. The information presented in this review provides essential insights 
      into the regulation of DC development and function, which might have implications 
      for developing novel therapeutic strategies for immune-related diseases.
CI  - Copyright (c) 2023 Zhang, Audiger, Chopin and Nutt.
FAU - Zhang, Shengbo
AU  - Zhang S
AD  - Immunology Division, Walter and Eliza Hall Institute of Medical Research, 
      Parkville, VIC, Australia.
AD  - Department of Medical Biology, University of Melbourne, Parkville, VIC, 
      Australia.
FAU - Audiger, Cindy
AU  - Audiger C
AD  - Immunology Division, Walter and Eliza Hall Institute of Medical Research, 
      Parkville, VIC, Australia.
AD  - Department of Medical Biology, University of Melbourne, Parkville, VIC, 
      Australia.
FAU - Chopin, Michael
AU  - Chopin M
AD  - Department of Biochemistry and Molecular Biology, Biomedicine Discovery 
      Institute, Monash University, Clayton, VIC, Australia.
FAU - Nutt, Stephen L
AU  - Nutt SL
AD  - Immunology Division, Walter and Eliza Hall Institute of Medical Research, 
      Parkville, VIC, Australia.
AD  - Department of Medical Biology, University of Melbourne, Parkville, VIC, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230714
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - *Gene Expression Regulation
MH  - Cell Differentiation
MH  - *Transcriptome
MH  - Dendritic Cells
PMC - PMC10382230
OTO - NOTNLM
OT  - IRF8
OT  - cDCs
OT  - dendritic cells
OT  - pDCs
OT  - transcription factor
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/31 06:43
MHDA- 2023/10/23 00:42
PMCR- 2023/01/01
CRDT- 2023/07/31 04:53
PHST- 2023/03/08 00:00 [received]
PHST- 2023/06/28 00:00 [accepted]
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/07/31 06:43 [pubmed]
PHST- 2023/07/31 04:53 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1182553 [doi]
PST - epublish
SO  - Front Immunol. 2023 Jul 14;14:1182553. doi: 10.3389/fimmu.2023.1182553. 
      eCollection 2023.