PMID- 37521830
OWN - NLM
STAT- Publisher
LR  - 20230928
IS  - 2090-2441 (Electronic)
IS  - 1110-8630 (Print)
IS  - 1110-8630 (Linking)
VI  - 23
IP  - 1
DP  - 2022
TI  - Dietary total antioxidant capacity interacts with a variant of chromosome 5q13-14 
      locus to influence cardio-metabolic risk factors among obese adults.
PG  - 117
LID - 10.1186/s43042-022-00328-3 [doi]
LID - 117
AB  - BACKGROUND: The association between cocaine- and amphetamine-regulated transcript 
      prepropeptide gene (CARTPT) and obesity-related outcomes has shown in the 
      epidemiological studies. Nevertheless, there is lack of data regarding the CARTPT 
      gene-diet interactions in terms of antioxidant potential of diet. So, this study 
      aimed to test CARTPT gene-dietary non-enzymatic antioxidant capacity (NEAC) 
      interactions on cardio-metabolic risk factors in obese individuals. METHODS AND 
      MATERIAL: The present cross-sectional study was carried out among 288 apparently 
      healthy obese adults within age range of 20-50 years. Antioxidant capacity of 
      diet was estimated by calculating the oxygen radical absorbance capacity (ORAC), 
      ferric reducing antioxidant power (FRAP), total radical-trapping antioxidant 
      parameter (TRAP) and Trolox equivalent antioxidant capacity (TEAC) using a 
      semiquantitative food frequency questionnaire (FFQ). Genotyping for CARTPT 
      rs2239670 polymorphism was conducted by polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) method. RESULTS: A significant 
      interaction was revealed between CARTPT rs2239670 and dietary ORAC on BMI 
      (P(Interaction) = 0.048) and fat mass percent (FM%) (P(Interaction) = 0.008); in 
      A allele carriers, higher adherence to the dietary ORAC was related to lower 
      level of BMI and FM%. And, the significant interactions were observed between 
      FRAP index and rs2239670 in relation to HOMA (P(Interaction) = 0.049) and QUICKI 
      (P(Interaction) = 0.048). Moreover, there were significant interactions of 
      rs2239670 with TRAP (P(Interaction) = 0.029) and TEAC (P(Interaction) = 0.034) on 
      the serum glucose level; individuals with AG genotype were more respondent to 
      higher intake of TRAP. CONCLUSION: The present study indicated that the 
      relationships between CARTPT rs2239670 and obesity and its-related metabolic 
      parameters depend on adherence to the dietary NEAC. Large prospective studies are 
      needed to confirm our findings.
CI  - (c) The Author(s) 2022.
FAU - Khodarahmi, Mahdieh
AU  - Khodarahmi M
AD  - Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 
      0001 2174 8913
FAU - Sobhrakhshan Khah, Amir
AU  - Sobhrakhshan Khah A
AD  - Sepehr Heart Center, Baharloo Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922
FAU - Farhangi, Mahdieh Abbasalizad
AU  - Farhangi MA
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, 
      Attar-neishabouri Ave, Golgasht St, Tabriz, 5165665931 Iran. GRID: grid.412888.f. 
      ISNI: 0000 0001 2174 8913
FAU - Siri, Goli
AU  - Siri G
AD  - Department of Internal Medicine, Amir-Alam Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922
FAU - Kahroba, Houman
AU  - Kahroba H
AD  - Department of Toxicogenomics, GROW School of Oncology and Development Biology, 
      Maastricht University, Maastricht, The Netherlands. GRID: grid.5012.6. ISNI: 0000 
      0001 0481 6099
AD  - Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. GRID: 
      grid.12155.32. ISNI: 0000 0001 0604 5662
LA  - eng
PT  - Journal Article
DEP - 20220805
PL  - Egypt
TA  - Egypt J Med Hum Genet
JT  - The Egyptian journal of medical human genetics
JID - 101151137
PMC - PMC9362403
OTO - NOTNLM
OT  - CARTPT
OT  - Gene-diet interaction
OT  - Metabolic factors
OT  - Obesity
OT  - Polymorphism
OT  - Total antioxidant capacity
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2022/01/01 00:00
MHDA- 2022/01/01 00:00
PMCR- 2022/08/05
CRDT- 2023/07/31 05:13
PHST- 2021/08/31 00:00 [received]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/01/01 00:00 [pubmed]
PHST- 2022/01/01 00:00 [medline]
PHST- 2023/07/31 05:13 [entrez]
PHST- 2022/08/05 00:00 [pmc-release]
AID - 328 [pii]
AID - 10.1186/s43042-022-00328-3 [doi]
PST - ppublish
SO  - Egypt J Med Hum Genet. 2022;23(1):117. doi: 10.1186/s43042-022-00328-3. Epub 2022 
      Aug 5.