PMID- 37522711
OWN - NLM
STAT- MEDLINE
DCOM- 20240326
LR  - 20240326
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 148
IP  - 4
DP  - 2024 Apr 1
TI  - Evaluation of Novel Targets, Including CC-Chemokine Receptor 4, in Adult T-Cell 
      Acute Lymphoblastic Leukemia/Lymphoma: A Mayo Clinic Clinical and Pathologic 
      Study.
PG  - 471-475
LID - 10.5858/arpa.2022-0482-OA [doi]
AB  - CONTEXT.-: Unlike B-cell acute lymphoblastic leukemia/lymphoma (ALL/LBL), there 
      have been few therapeutic advances in T-cell ALL (T-ALL)/LBL, an aggressive 
      ALL/LBL subtype. OBJECTIVE.-: To perform a focused tissue array study to 
      elucidate tumor markers of therapeutic potential in T-ALL/LBL. DESIGN.-: Using 
      immunohistochemistry, we evaluated expression of leukemic antigens of interest, 
      specifically CC-chemokine receptor 4 (CCR4), among others, on available remnant 
      diagnostic material, including tumor tissue slides obtained from formalin-fixed, 
      paraffin-embedded preserved tissues. RESULTS.-: Our analysis identified, for the 
      first time, expression of CCR4 in T-ALL/LBL in 11 of 27 cases (40.7%) and 
      confirmed common expression of BCL2, CD38, and CD47, as reported previously. We 
      also identified the expression of CD123 in 4 of 26 cases (15.4%), whereas BCL6 
      and PDL1 were expressed in a small number of T-ALL/LBL cases. The potential novel 
      target CCR4 was significantly more common in the Pre/Pro-T immunophenotypic 
      subtype, 6 of 9 (66.7%, P = .01). No additional differences in clinical and 
      epidemiologic variables were noted among positive or negative CCR4 cases. 
      CONCLUSIONS.-: These findings support preclinical and clinical testing of 
      therapies targeting CCR4, CD47, BCL2, CD38, and CD123 in T-ALL/LBL, and may help 
      guide the development of targeted clinical trials in T-ALL/LBL, a rare disease in 
      urgent need of novel therapies.
CI  - (c) 2024 College of American Pathologists.
FAU - Khurana, Sharad
AU  - Khurana S
AD  - From the Division of Hematology/Oncology, University of Arizona Cancer Center, 
      Tucson (Khurana).
FAU - Heckman, Michael G
AU  - Heckman MG
AD  - the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and 
      Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and 
      Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville.
FAU - Craig, Fiona E
AU  - Craig FE
AD  - the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology 
      (Sproat), Mayo Clinic Arizona, Phoenix.
FAU - Cochuyt, Jordan J
AU  - Cochuyt JJ
AD  - the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and 
      Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and 
      Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville.
FAU - Greipp, Patricia
AU  - Greipp P
AD  - the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo 
      Clinic, Rochester, Minnesota.
FAU - Rahman, Zaid Abdel
AU  - Rahman ZA
AD  - the Division of Hematology and Medical Oncology, Sanford Roger Maris Cancer 
      Center, Fargo, North Dakota (Rahman).
FAU - Sproat, Lisa Z
AU  - Sproat LZ
AD  - the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology 
      (Sproat), Mayo Clinic Arizona, Phoenix.
FAU - Litzow, Mark
AU  - Litzow M
AD  - the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo 
      Clinic, Rochester, Minnesota.
FAU - Foran, James M
AU  - Foran JM
AD  - the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and 
      Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and 
      Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville.
FAU - Jiang, Liuyan Jennifer
AU  - Jiang LJ
AD  - the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and 
      Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and 
      Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
RN  - 0 (CD47 Antigen)
RN  - 0 (Receptors, CCR4)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/pathology
MH  - CD47 Antigen
MH  - Receptors, CCR4
MH  - Interleukin-3 Receptor alpha Subunit
MH  - *Lymphoma
MH  - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/pathology
MH  - *Lymphoma, B-Cell
MH  - T-Lymphocytes/pathology
MH  - Proto-Oncogene Proteins c-bcl-2
EDAT- 2023/07/31 13:09
MHDA- 2024/03/26 06:44
CRDT- 2023/07/31 09:02
PHST- 2023/04/20 00:00 [accepted]
PHST- 2024/03/26 06:44 [medline]
PHST- 2023/07/31 13:09 [pubmed]
PHST- 2023/07/31 09:02 [entrez]
AID - 494632 [pii]
AID - 10.5858/arpa.2022-0482-OA [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2024 Apr 1;148(4):471-475. doi: 10.5858/arpa.2022-0482-OA.