PMID- 37523928 OWN - NLM STAT- MEDLINE DCOM- 20230913 LR - 20230913 IS - 1878-0334 (Electronic) IS - 1871-4021 (Linking) VI - 17 IP - 8 DP - 2023 Aug TI - The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. PG - 102824 LID - S1871-4021(23)00120-0 [pii] LID - 10.1016/j.dsx.2023.102824 [doi] AB - BACKGROUND AND AIM: It has been suggested that taking vitamin C supplements may improve glycemic control in patients with type 2 diabetes mellitus (T2DM). However, there has not been a thorough evaluation of the actual impact or certainty of the findings. This systematic review and meta-analysis was conducted to determine the effect of vitamin C supplementation on glycemic profile in T2DM patients. METHODS: A systematic search was performed across online databases including Scopus, Web of Science, and PubMed/Medline to identify relevant randomized controlled trials (RCTs) published until July 2022. A random-effects model was applied for the meta-analysis. RESULTS: The present meta-analysis included a total of 22 RCTs with 1447 patients diagnosed with T2DM.A pooled analysis revealed a significant decrease in levels of serum hemoglobin A1c (HbA1c), fasting insulin, and fasting blood glucose (FBG) in vitamin C-treated T2DM patients compared with their untreated counterparts. The dose-response evaluation displayed a substantial linear association between the intervention duration and changes in serum HbA1c levels. However, the analysis did not demonstrate any significant effect of vitamin C on serum values of homeostasis model assessment of insulin resistance(HOMA-IR) in diabetic patients. Subgroup analyses indicated that high-dose vitamin C administration (>/=1000 mg/d) considerably decreased serum HOMA-IR levels. CONCLUSION: These findings suggest that long-term (>/=12 weeks) and high-dose vitamin C supplementation (>/=1000 mg/d) may ameliorate glycemic profile in T2DM patients. However, additional high-quality RCTs are necessary to validate these results. CI - Copyright (c) 2023 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved. FAU - Nosratabadi, Saeed AU - Nosratabadi S AD - Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: saeednosratabadi1995@gmail.com. FAU - Ashtary-Larky, Damoon AU - Ashtary-Larky D AD - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Damoon_ashtary@yahoo.com. FAU - Hosseini, Fatemeh AU - Hosseini F AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science, Tehran, Iran. Electronic address: Sfatemehosseini95@gmail.com. FAU - Namkhah, Zahra AU - Namkhah Z AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: namkhah.zahra@gmail.com. FAU - Mohammadi, Shooka AU - Mohammadi S AD - Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: shooka.mohammadi@gmail.com. FAU - Salamat, Shekoufeh AU - Salamat S AD - Department of Nutrition, Faculty of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: shekooofeh@yahoo.com. FAU - Nadery, Maryam AU - Nadery M AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA. Electronic address: mnade017@fiu.edu. FAU - Yarmand, Sazin AU - Yarmand S AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: yarmandsazin@yahoo.com. FAU - Zamani, Mohammad AU - Zamani M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: md_zamany@yahoo.com. FAU - Wong, Alexei AU - Wong A AD - Department of Health and Human Performance, Marymount University, Arlington, Virginia, USA. Electronic address: awong@marymount.edu. FAU - Asbaghi, Omid AU - Asbaghi O AD - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: omid.asbaghi@gmail.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20230707 PL - Netherlands TA - Diabetes Metab Syndr JT - Diabetes & metabolic syndrome JID - 101462250 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 1406-16-2 (Vitamin D) RN - 0 (Vitamins) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Humans MH - Glycated Hemoglobin MH - *Blood Glucose/analysis MH - Vitamin D MH - Glycemic Control MH - *Diabetes Mellitus, Type 2/drug therapy MH - Vitamins/therapeutic use MH - Dietary Supplements MH - Ascorbic Acid/therapeutic use OTO - NOTNLM OT - Diabetes OT - Glycemic profile OT - Hyperglycemia OT - Meta-analysis OT - Systematic review OT - Vitamin C COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2023/08/01 01:08 MHDA- 2023/09/13 06:42 CRDT- 2023/07/31 18:06 PHST- 2022/08/06 00:00 [received] PHST- 2023/06/21 00:00 [revised] PHST- 2023/06/26 00:00 [accepted] PHST- 2023/09/13 06:42 [medline] PHST- 2023/08/01 01:08 [pubmed] PHST- 2023/07/31 18:06 [entrez] AID - S1871-4021(23)00120-0 [pii] AID - 10.1016/j.dsx.2023.102824 [doi] PST - ppublish SO - Diabetes Metab Syndr. 2023 Aug;17(8):102824. doi: 10.1016/j.dsx.2023.102824. Epub 2023 Jul 7.