PMID- 37524423
OWN - NLM
STAT- MEDLINE
DCOM- 20231005
LR  - 20240426
IS  - 1473-4893 (Electronic)
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 23
IP  - 4
DP  - 2023 Jul
TI  - Sleep measures and cardiovascular disease in type 2 diabetes mellitus.
PG  - 380-386
LID - 10.7861/clinmed.2022-0442 [doi]
AB  - OBJECTIVE: The objective of this study was to assess whether poor sleep is 
      independently associated with cardiovascular disease in people with type 2 
      diabetes mellitus (T2DM). METHODS: A cross-sectional study was performed in 
      subjects with T2DM aged between 40 and 80 years. Sleep assessment was achieved by 
      actigraphy and Pittsburgh Sleep Quality Index (PSQI) score. RESULTS: The study 
      population comprised 108 subjects with T2DM. The mean age was 64.9 years, the 
      median diabetes duration was 6 years and 73.1% were men. No association was shown 
      between sleep parameters as assessed by actigraphy and T2DM-associated micro- and 
      macrovascular complications. However, sleep quality as assessed by PSQI was 
      significantly associated with macrovascular disease in univariate analysis. 
      Multivariate logistic regression analysis showed red blood cell distribution 
      width (RDW) (odds ratio (OR) 1.79, p=0.018) and good sleep quality (OR 0.35, 
      p=0.017) to be independently associated. Binary logistic regression analysis 
      revealed that body mass index (BMI) (OR 1.11, p=0.024), RDW (OR 1.95, p=0.007) 
      and Center for Epidemiologic Studies Depression score (OR 1.06, p=0.012] were 
      independently associated with abnormal carotid intima-media thickness (CIMT). 
      CONCLUSIONS: Poor sleep quality and higher RDW levels are associated with 
      macrovascular disease in a T2DM population. Increased BMI as well as depression 
      also appear to have an independent role in subclinical atherosclerosis, as 
      assessed by CIMT.
CI  - (c) Royal College of Physicians 2023. All rights reserved.
FAU - Magri, Caroline J
AU  - Magri CJ
AD  - Mater Dei Hospital, Malta.
FAU - Xuereb, Sara
AU  - Xuereb S
AD  - Mater Dei Hospital, Malta.
FAU - Xuereb, Rachel-Anne
AU  - Xuereb RA
AD  - Mater Dei Hospital, Malta.
FAU - Xuereb, Robert G
AU  - Xuereb RG
AD  - Mater Dei Hospital, Malta.
FAU - Fava, Stephen
AU  - Fava S
AD  - University of Malta, Malta, and consultant endocrinologist, Mater Dei Hospital, 
      Malta stephen.fava@um.edu.mt.
FAU - Galea, Joseph
AU  - Galea J
AD  - University of Malta, Malta, and consultant cardiac surgeon, Mater Dei Hospital, 
      Malta.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - Male
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Cardiovascular Diseases/epidemiology
MH  - Risk Factors
MH  - Cross-Sectional Studies
MH  - Carotid Intima-Media Thickness
MH  - Sleep
PMC - PMC10541029
OTO - NOTNLM
OT  - actigraphy
OT  - cardiovascular disease
OT  - sleep
OT  - type 2 diabetes mellitus
EDAT- 2023/08/01 01:08
MHDA- 2023/10/05 06:44
PMCR- 2023/07/01
CRDT- 2023/07/31 20:42
PHST- 2023/10/05 06:44 [medline]
PHST- 2023/08/01 01:08 [pubmed]
PHST- 2023/07/31 20:42 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - S1470-2118(24)04586-X [pii]
AID - clinmedicine [pii]
AID - 10.7861/clinmed.2022-0442 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2023 Jul;23(4):380-386. doi: 10.7861/clinmed.2022-0442.