PMID- 37524504
OWN - NLM
STAT- Publisher
LR  - 20231015
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 36
IP  - 11
DP  - 2023 Nov
TI  - NMR metabolomics study of chronic low-dose exposure to a cocktail of persistent 
      organic pollutants.
PG  - e5006
LID - 10.1002/nbm.5006 [doi]
AB  - Nowadays, exposure to endocrine-disrupting chemicals (EDCs), including persistent 
      organic pollutants (POPs), is one of the most critical threats to public health. 
      EDCs are chemicals that mimic, block, or interfere with hormones in the body's 
      endocrine system and have been associated with a wide range of health issues. 
      This innovative, untargeted metabolomics study investigates chronic low-dose 
      internal exposure to a cocktail of POPs on multiple tissues that are known to 
      accumulate these lipophilic compounds. Interestingly, the metabolic response 
      differs among selected tissues/organs in mice. In the liver, we observed a 
      dynamic effect according to the exposure time and the doses of POPs. In the brain 
      tissue, the situation is the opposite, leading to the conclusion that the 
      presence of POPs immediately gives a saturated effect that is independent of the 
      dose and the duration of exposure studied. By contrast, for the adipose tissues, 
      nearly no effect is observed. This metabolic profiling leads to a holistic and 
      dynamic overview of the main metabolic pathways impacted in lipophilic tissues by 
      a cocktail of POPs.
CI  - (c) 2023 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
FAU - Lucas-Torres, Covadonga
AU  - Lucas-Torres C
AD  - CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et 
      Toxicologiques, Universite Paris Cite, Paris, France.
FAU - Caradeuc, Cedric
AU  - Caradeuc C
AD  - CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et 
      Toxicologiques, Universite Paris Cite, Paris, France.
FAU - Prieur, Laura
AU  - Prieur L
AD  - CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et 
      Toxicologiques, Universite Paris Cite, Paris, France.
FAU - Djemai, Haidar
AU  - Djemai H
AD  - INSERM UMR-S 1124, Environmental Toxicity, Therapeutic Targets, Cellular 
      Signaling & Biomarkers (T3S), Universite Paris Cite, Paris, France.
FAU - Youssef, Layale
AU  - Youssef L
AD  - INSERM UMR-S 1124, Environmental Toxicity, Therapeutic Targets, Cellular 
      Signaling & Biomarkers (T3S), Universite Paris Cite, Paris, France.
FAU - Noirez, Philippe
AU  - Noirez P
AD  - INSERM UMR-S 1124, Environmental Toxicity, Therapeutic Targets, Cellular 
      Signaling & Biomarkers (T3S), Universite Paris Cite, Paris, France.
AD  - Performance, Sante, Metrologie, Societe (PSMS), UFR STAPS, Campus Moulin de la 
      Housse, Universite de Reims Champagne-Ardenne, Reims, France.
AD  - Departement des Sciences de l'Activite Physique, Universite du Quebec A Montreal 
      (UQAM), Montreal, Quebec, Canada.
FAU - Coumoul, Xavier
AU  - Coumoul X
AD  - INSERM UMR-S 1124, Environmental Toxicity, Therapeutic Targets, Cellular 
      Signaling & Biomarkers (T3S), Universite Paris Cite, Paris, France.
FAU - Audouze, Karine
AU  - Audouze K
AD  - INSERM UMR-S 1124, Environmental Toxicity, Therapeutic Targets, Cellular 
      Signaling & Biomarkers (T3S), Universite Paris Cite, Paris, France.
FAU - Giraud, Nicolas
AU  - Giraud N
AD  - CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et 
      Toxicologiques, Universite Paris Cite, Paris, France.
FAU - Bertho, Gildas
AU  - Bertho G
AD  - CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et 
      Toxicologiques, Universite Paris Cite, Paris, France.
LA  - eng
GR  - 18-CE-34-0001/Agence Nationale de la Recherche/
GR  - ITMO Cancer d'AVIESAN/
PT  - Journal Article
DEP - 20230731
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
OTO - NOTNLM
OT  - EDCs
OT  - NMR
OT  - POPs
OT  - chronic exposure
OT  - low-dose exposure
OT  - multitissue study
OT  - untargeted metabolomics
EDAT- 2023/08/01 01:08
MHDA- 2023/08/01 01:08
CRDT- 2023/07/31 21:12
PHST- 2023/06/09 00:00 [revised]
PHST- 2023/04/04 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/08/01 01:08 [pubmed]
PHST- 2023/08/01 01:08 [medline]
PHST- 2023/07/31 21:12 [entrez]
AID - 10.1002/nbm.5006 [doi]
PST - ppublish
SO  - NMR Biomed. 2023 Nov;36(11):e5006. doi: 10.1002/nbm.5006. Epub 2023 Jul 31.