PMID- 37524597
OWN - NLM
STAT- Publisher
LR  - 20230731
IS  - 0125-9326 (Print)
IS  - 0125-9326 (Linking)
VI  - 55
IP  - 2
DP  - 2023 Apr
TI  - Prevalence and Factors Related to Hypovitaminosis D in Type 2 Diabetes Mellitus 
      Patients with Depression.
PG  - 150-157
AB  - BACKGROUND: The prevalence of hypovitaminosis D (hypoD) in patients with type 2 
      diabetes mellitus (T2DM) and depression has not been documented. In addition, the 
      risk factors are unknown. This study aimed to identify the prevalence of and risk 
      factors for hypoD in patients with T2DM who also have depression. METHODS: 118 
      patients with T2DM who visited the outpatient endocrinology clinics at Cipto 
      Mangunkusumo National Hospital between December 2019-September 2022 provided the 
      clinical and demographic data for this cross- sectional study, including body 
      mass index, blood pressure, glycosylated haemoglobin (HbA1c), lipid profiles, 
      therapy, gender, age, marital status, and educational background. We used The 
      Beck Depression Inventory II (BDI II) to evaluate depression. We used 
      enzyme-linked immunosorbent assay kit to assess the dependent variable: serum 
      vitamin D. We characterized serum vitamin D levels into three groups (normal, 30 
      ng/mL; insufficient, 20-29 ng/mL; deficient, 20 ng/mL). We also used analyses of 
      variance to examine the anthropometric, clinical, and biochemical factors between 
      the three groups. RESULTS: 118 subjects with T2DM. Their median age was 56 years 
      old (48, 75-60 years old), with a BDI II score of 17 (15-19), and a serum 
      concentration of vitamin D. The D level was 18.3 ng/mL (9.17-29.46 ng/mL). Only 
      21.8% of patients with T2DM and depression had sufficient levels of vitamin D. We 
      used multivariable analysis of variance model to examine the associations between 
      age, BDI II score, HbA1c, and systolic and diastolic blood pressure with vitamin 
      D level. Age and BDI II score both had a statistically significant effect on 
      vitamin D levels. CONCLUSION: This cross-sectional study discovered that patients 
      with T2DM and depression had a high prevalence (77.7%) of hypoD. Age and BDI II 
      score both affected differences in vitamin D levels with statistical 
      significance.
FAU - Putranto, Rudi
AU  - Putranto R
AD  - Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - 
      Cipto Mangunkusumo Hospital, Jakarta, Indonesia. putranto.rudi09@gmail.com.
FAU - Setiati, Siti
AU  - Setiati S
FAU - Nasrun, Martina W
AU  - Nasrun MW
FAU - Witjaksono, Fiastuti
AU  - Witjaksono F
FAU - Immanuel, Suzanna
AU  - Immanuel S
FAU - Subekti, Imam
AU  - Subekti I
FAU - Harimurti, Kuntjoro
AU  - Harimurti K
FAU - Siswanto, Agus
AU  - Siswanto A
FAU - Shatri, Hamzah
AU  - Shatri H
FAU - Suwarto, Suhendro
AU  - Suwarto S
LA  - eng
PT  - Journal Article
PL  - Indonesia
TA  - Acta Med Indones
JT  - Acta medica Indonesiana
JID - 7901042
SB  - IM
OTO - NOTNLM
OT  - depression
OT  - hypovitaminosis
OT  - type 2 diabetes mellitus
EDAT- 2023/08/01 01:08
MHDA- 2023/08/01 01:08
CRDT- 2023/07/31 21:53
PHST- 2023/08/01 01:08 [medline]
PHST- 2023/08/01 01:08 [pubmed]
PHST- 2023/07/31 21:53 [entrez]
PST - ppublish
SO  - Acta Med Indones. 2023 Apr;55(2):150-157.