PMID- 37524663
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 22
IP  - 3
DP  - 2023 Jun 16
TI  - Formulation and Evaluation of the Anti-inflammatory, Anti-oxidative, and 
      Anti-remodelling Effects of the Niosomal Myrtenol on the Lungs of Asthmatic Rats.
PG  - 265-280
LID - 10.18502/ijaai.v22i3.13054 [doi]
AB  - Asthma is a common chronic allergic disease that affects a significant percentage 
      of the world's population. Niosomes are nanoparticles consisting of non-ionic 
      surfactants that can be used for drug delivery. This research was designed to 
      investigate the impacts of inhalation of simple and niosomal forms of myrtenol 
      against adverse consequences of asthma in rats. Asthma induction was performed 
      via injection of ovalbumin, followed by its inhalation. Niosomes were created by 
      a heating protocol, and their physicochemical features were evaluated. Forty-nine 
      male Wistar rats were allotted into 7 groups (n=7 each): Control (CTL), vacant 
      niosome (VN), Asthma, Asthma+VN, Asthma+SM (simple myrtenol), Asthma+NM (niosomal 
      myrtenol), and Asthma+B (budesonide). Lung remodeling, serum immunoglobulin E 
      (IgE), inflammatory  and cytokines, and antioxidant factors in the lung tissue 
      and bronchoalveolar fluid (BALF), as well as), were evaluated. The results showed 
      that myrtenol-loaded niosomes had appropriate encapsulation efficiency, kinetic 
      release, size, and zeta potential. The thickness of the epithelial cell layer in 
      the lungs, as well as cell infiltration, fibrosis, IgE, reactive oxygen species, 
      interleukin (IL)-6, and tumor nuclear factor alpha (TNF-alpha) levels, decreased 
      significantly. In contrast, superoxide dismutase and glutathione peroxide 
      activity increased significantly in the serum and BALF of the treated groups. The 
      niosomal form of myrtenol revealed a higher efficacy than simple myrtenol and was 
      similar to budesonide in ameliorating asthma indices.  Inhalation of simple and 
      niosomal forms of myrtenol improved the detrimental changes in the asthmatic 
      lung. The niosomal form induced more prominent anti-asthmatic effects comparable 
      to those of budesonide.
FAU - Rajizadeh, Mohammad Amin
AU  - Rajizadeh MA
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran AND Department of Physiology and Pharmacology, 
      Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran. 
      aminrajizadeh@yahoo.com.
FAU - Nematollahi, Mohammad Hadi
AU  - Nematollahi MH
AD  - Herbal and Traditional Medicines Research Center, Kerman University of Medical 
      Sciences, Kerman, Iran. mh.nematollahi@yahoo.com.
FAU - Jafari, Elham
AU  - Jafari E
AD  - Department of Pathology, Pathology and Stem Cells Research Center, School of 
      Medicine, Kerman University of Medical Science, Kerman, Iran. ejfarda@yahoo.com.
FAU - Bejeshk, Mohammad Abbas
AU  - Bejeshk MA
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran AND Department of Physiology and Pharmacology, 
      Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran. 
      m.bejeshk@yahoo.com.
FAU - Mehrabani, Mehrnaz
AU  - Mehrabani M
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran. mehrnaz.mehrabani@yahoo.com.
FAU - Rostamzadeh, Farzaneh
AU  - Rostamzadeh F
AD  - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical 
      Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. 
      far_rostamzadeh@yahoo.com.
FAU - Samareh Fekri, Mitra
AU  - Samareh Fekri M
AD  - Cardiovascular Research Center, Institute of Basic and Clinical Physiology 
      Sciences, Kerman University of Medical Sciences, Kerman, Iran. 
      m_samareh@kmu.ac.ir.
FAU - Najafipour, Hamid
AU  - Najafipour H
AD  - Cardiovascular Research Center, Institute of Basic and Clinical Physiology 
      Sciences, Kerman University of Medical Sciences, Kerman, Iran. 
      najafipourh@yahoo.co.uk.
LA  - eng
PT  - Journal Article
DEP - 20230616
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - S1B8392IQY (myrtenol)
RN  - 0 (Liposomes)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 51333-22-3 (Budesonide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Interleukin-6)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Liposomes/adverse effects
MH  - Rats, Wistar
MH  - *Asthma/drug therapy/pathology
MH  - Lung/pathology
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Cytokines
MH  - Budesonide/adverse effects
MH  - Immunoglobulin E
MH  - Interleukin-6
MH  - Ovalbumin
MH  - Disease Models, Animal
MH  - Bronchoalveolar Lavage Fluid
OTO - NOTNLM
OT  - Allergic asthma
OT  - Histopathological changes
OT  - Inflammation
OT  - Niosomes myrtenol
OT  - Oxidative stress
EDAT- 2023/08/01 01:08
MHDA- 2023/10/23 00:42
CRDT- 2023/07/31 22:24
PHST- 2023/01/08 00:00 [received]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/08/01 01:08 [pubmed]
PHST- 2023/07/31 22:24 [entrez]
AID - 10.18502/ijaai.v22i3.13054 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):265-280. doi: 
      10.18502/ijaai.v22i3.13054.