PMID- 37526051
OWN - NLM
STAT- MEDLINE
DCOM- 20231110
LR  - 20231110
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 37
IP  - 11
DP  - 2023 Nov
TI  - Association between cannabis use and risk of diabetes mellitus type 2: A 
      systematic review and meta-analysis.
PG  - 5092-5108
LID - 10.1002/ptr.7973 [doi]
AB  - BACKGROUND: Cannabis consumption exerts multiple effects on metabolism via 
      various pathways, including glucose regulation and insulin secretion. Studies 
      concerning the association between cannabis use and diabetes mellitus type 2 are 
      discrepant. OBJECTIVE: This study was conducted to evaluate the association 
      between cannabis use and type 2 diabetes mellitus (T2DM). SEARCH METHODS: We 
      searched PubMed, Scopus, Embase, Proquest, Web of Science, and Cochrane Library 
      with no time, language or study types restriction until July 1, 2022, using 
      various forms of "cannabis" and "diabetes mellitus" search terms. SELECTION 
      CRITERIA: Randomized control trials, cohort, and case-control studies 
      investigating the relationship between cannabis consumption and diabetes mellitus 
      type 2 were included. DATA COLLECTION AND ANALYSIS: The Newcastle-Ottawa scale 
      was used to assess the quality of studies. We pooled odds ratio (OR) with 95% 
      confidence interval (CI) using the random-effects model, generic inverse variance 
      method, DerSimonian and Laird approach. MAIN RESULTS: A meta-analysis of seven 
      studies, containing 11 surveys and 4 cohorts, revealed that the odds of 
      developing T2DM in individuals exposed to cannabis was 0.48 times (95% CI: 0.39 
      to 0.59) lower than in those without cannabis exposure. CONCLUSIONS: A protective 
      effect of cannabis consumption on the odds of diabetes mellitus type 2 
      development has been suggested. Yet given the considerable interstudy 
      heterogeneity, the upward trend of cannabis consumption and cannabis legalization 
      is recommended to conduct studies with higher levels of evidence.
CI  - (c) 2023 John Wiley & Sons, Ltd.
FAU - Mousavi, Seyed Ehsan
AU  - Mousavi SE
AUID- ORCID: 0000-0003-4747-5639
AD  - Student Research Committee, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Tondro Anamag, Farhad
AU  - Tondro Anamag F
AD  - Student Research Committee, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Sanaie, Sarvin
AU  - Sanaie S
AUID- ORCID: 0000-0003-2325-5631
AD  - Research Center for Integrative Medicine in Aging, Aging Research Institute, 
      Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230801
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Cannabis/adverse effects
MH  - Insulin Secretion
MH  - Case-Control Studies
OTO - NOTNLM
OT  - cannabis
OT  - diabetes mellitus, type 2
OT  - marijuana smoking
OT  - meta-analysis
EDAT- 2023/08/01 06:44
MHDA- 2023/11/10 06:45
CRDT- 2023/08/01 05:30
PHST- 2023/05/19 00:00 [revised]
PHST- 2023/01/22 00:00 [received]
PHST- 2023/07/16 00:00 [accepted]
PHST- 2023/11/10 06:45 [medline]
PHST- 2023/08/01 06:44 [pubmed]
PHST- 2023/08/01 05:30 [entrez]
AID - 10.1002/ptr.7973 [doi]
PST - ppublish
SO  - Phytother Res. 2023 Nov;37(11):5092-5108. doi: 10.1002/ptr.7973. Epub 2023 Aug 1.