PMID- 37526540
OWN - NLM
STAT- MEDLINE
DCOM- 20230802
LR  - 20230802
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 308
IP  - 2
DP  - 2023 Aug
TI  - Multiparametric MRI and Radiomics for the Prediction of HER2-Zero, -Low, and 
      -Positive Breast Cancers.
PG  - e222646
LID - 10.1148/radiol.222646 [doi]
AB  - Background Half of breast cancers exhibit low expression levels of human 
      epidermal growth factor receptor 2 (HER2) and can be targeted by new 
      antibody-drug conjugates. The imaging differences between HER2-zero 
      (immunohistochemistry [IHC] score of 0), HER2-low (IHC score of 1+ or 2+ with 
      negative findings at fluorescence in situ hybridization [FISH]), and 
      HER2-positive (IHC score of 2+ with positive findings at FISH or IHC score of 3+) 
      breast cancers were unknown. Purpose To assess whether multiparametric dynamic 
      contrast-enhanced MRI-based radiomic features can help distinguish HER2 
      expressions in breast cancer. Materials and Methods This study included women 
      with breast cancer who underwent MRI at two different centers between December 
      2020 and December 2022. Tumor segmentation and radiomic feature extraction were 
      performed on T2-weighted and dynamic contrast-enhanced T1-weighted images. 
      Unsupervised correlation analysis of reproducible features and least absolute 
      shrinkage and selector operation were used for the selection of features to build 
      a radiomics signature. The area under the receiver operating characteristic curve 
      (AUC) was used to assess the performance of the radiomic signature. Multivariable 
      logistic regression was used to identify independent predictors for 
      distinguishing HER2 expressions in both the training and prospectively acquired 
      external data set. Results The training set included 208 patients from center 1 
      (mean age, 53 years +/- 14 [SD]), and the external test set included 131 patients 
      from center 2 (mean age, 54 years +/- 13). In the external test data set, the 
      radiomic signature achieved an AUC of 0.80 (95% CI: 0.71, 0.89) for 
      distinguishing HER2-low and -positive tumors versus HER2-zero tumors and was a 
      significant predictive factor for distinguishing these two groups (odds ratio = 
      7.6; 95% CI: 2.9, 19.8; P < .001). Among HER2-low or -positive breast cancers, 
      histology type, associated nonmass enhancement, and multiple lesions at MRI had 
      an AUC of 0.77 (95% CI: 0.68, 0.86) in the external test set for the prediction 
      of HER2-positive versus HER2-low cancers. Conclusion The radiomic signature and 
      tumor descriptors from multiparametric breast MRI may predict distinct HER2 
      expressions of breast cancers with therapeutic implications. (c) RSNA, 2023 
      Supplemental material is available for this article. See also the editorial by 
      Kataoka and Honda in this issue.
FAU - Ramtohul, Toulsie
AU  - Ramtohul T
AUID- ORCID: 0000-0002-8440-7785
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Djerroudi, Lounes
AU  - Djerroudi L
AUID- ORCID: 0000-0002-5007-2964
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Lissavalid, Emilie
AU  - Lissavalid E
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Nhy, Caroline
AU  - Nhy C
AUID- ORCID: 0009-0009-2660-7381
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Redon, Louis
AU  - Redon L
AUID- ORCID: 0009-0009-2133-2091
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Ikni, Laura
AU  - Ikni L
AUID- ORCID: 0009-0003-5339-6918
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Djelouah, Manel
AU  - Djelouah M
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Journo, Gabrielle
AU  - Journo G
AUID- ORCID: 0000-0002-7692-5734
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Menet, Emmanuelle
AU  - Menet E
AUID- ORCID: 0009-0001-2643-4718
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Cabel, Luc
AU  - Cabel L
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Malhaire, Caroline
AU  - Malhaire C
AUID- ORCID: 0000-0002-9235-9816
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
FAU - Tardivon, Anne
AU  - Tardivon A
AUID- ORCID: 0000-0002-2371-3391
AD  - From the Department of Radiology (T.R., E.L., C.N., L.R., L.I., M.D., C.M., 
      A.T.), Department of Diagnostic and Theranostic Medicine-Pathology (L.D.), and 
      Department of Medical Oncology (L.C.), Institut Curie Paris, PSL Research 
      University, 26 rue d'Ulm, Paris, France; Department of Radiology (G.J.) and 
      Department of Diagnostic and Theranostic Medicine-Pathology (E.M.), Institut 
      Curie St Cloud, PSL Research University, St Cloud, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2023 Aug;308(2):e231649. PMID: 37526546
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - *Multiparametric Magnetic Resonance Imaging/methods
MH  - *Breast Neoplasms/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging/methods
MH  - Breast/pathology
MH  - Retrospective Studies
EDAT- 2023/08/01 13:09
MHDA- 2023/08/02 06:42
CRDT- 2023/08/01 09:53
PHST- 2023/08/02 06:42 [medline]
PHST- 2023/08/01 13:09 [pubmed]
PHST- 2023/08/01 09:53 [entrez]
AID - 10.1148/radiol.222646 [doi]
PST - ppublish
SO  - Radiology. 2023 Aug;308(2):e222646. doi: 10.1148/radiol.222646.