PMID- 37528246
OWN - NLM
STAT- MEDLINE
DCOM- 20240326
LR  - 20240326
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 193
IP  - 2
DP  - 2024 Apr
TI  - Prognosticating acute traumatic spinal cord injury using Neurofilament (NF), 
      Neuron Specific Enolase (NSE), Matrix Metalloproteinases (MMPs), and S-100B as 
      biomarkers.
PG  - 769-775
LID - 10.1007/s11845-023-03476-6 [doi]
AB  - BACKGROUND: Spinal cord injury (SCI) can result in lifelong disability. 
      Currently, the literature suggests that biomarkers are helpful in prognosticating 
      SCI, but there is no specific biomarker to date. This is the first study that 
      predicted the prognosis dynamically using biomarkers. AIM: To elucidate the role 
      of biomarkers in prognosticating acute traumatic SCI. METHODS: Blood samples were 
      obtained from 35 patients of acute traumatic SCI at presentation, immediate 
      post-op, and at 6 weeks. At 6 months follow-up, patients were divided into two 
      groups, i.e, improved and non-improved based on the improvement in the ASIA grade 
      compared to presentation. A non-parametric test was used for comparing mean NSE, 
      MMP-2, S100-B, and NF serum levels at presentation, immediate post-op, and 6 
      weeks post-op follow-up between the two groups. RESULTS: There was a significant 
      difference (p = 0.03) in the NF values at presentation between the two groups. 
      The difference of NSE values at 6 weeks was also significant (p = 0.016) between 
      the two groups. S-100B levels were also significantly different between both 
      groups at presentation (p=0.016), and at the immediate post-op stage (p=0.007). 
      MMP-2 levels neither displayed any specific trend nor any significant difference 
      between the two groups. CONCLUSION: Higher NF values at presentation, and higher 
      S-100B levels at presentation and immediate post-operative period correlated with 
      poor outcome. Also, increased NSE values after surgery are indicative of no 
      improvement. These levels can be used at various stages to predict the prognosis. 
      However, further studies are required on this topic extensively to know the exact 
      cut-off values of these markers to predict the prognosis accurately. CLINICAL 
      TRIALS REGISTRY NUMBER: REF/2020/01/030616.
CI  - (c) 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in 
      Ireland.
FAU - Paragond, Sachin
AU  - Paragond S
AD  - Department of Orthopaedics, ESIC Medical College and Hospital, Kalaburagi, 
      Karnataka, India.
FAU - Dhatt, Sarvdeep Singh
AU  - Dhatt SS
AD  - Department of Orthopaedics, PGIMER, Chandigarh, India.
FAU - Kumar, Vishal
AU  - Kumar V
AD  - Department of Orthopaedics, PGIMER, Chandigarh, India. drkumarvishal@gmail.com.
FAU - Zohmangaihi, Deepy
AU  - Zohmangaihi D
AD  - Department of Biochemistry, PGIMER, Chandigarh, India.
FAU - Gaurav, Ankit
AU  - Gaurav A
AD  - Department of Orthopaedics, PGIMER, Chandigarh, India.
FAU - Neradi, Deepak
AU  - Neradi D
AD  - Department of Orthopaedics, PGIMER, Chandigarh, India.
FAU - Pal, Arnab
AU  - Pal A
AD  - Department of Biochemistry, PGIMER, Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20230802
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (Biomarkers)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Humans
MH  - *Matrix Metalloproteinase 2
MH  - S100 Calcium Binding Protein beta Subunit
MH  - Intermediate Filaments
MH  - Biomarkers
MH  - *Spinal Cord Injuries
MH  - Phosphopyruvate Hydratase
MH  - Matrix Metalloproteinases
OTO - NOTNLM
OT  - Biomarkers
OT  - MMP-2
OT  - NF
OT  - NSE
OT  - Prognosis
OT  - S100-B
OT  - SCI
OT  - Traumatic
EDAT- 2023/08/02 01:07
MHDA- 2024/03/26 06:44
CRDT- 2023/08/01 23:29
PHST- 2023/04/17 00:00 [received]
PHST- 2023/07/24 00:00 [accepted]
PHST- 2024/03/26 06:44 [medline]
PHST- 2023/08/02 01:07 [pubmed]
PHST- 2023/08/01 23:29 [entrez]
AID - 10.1007/s11845-023-03476-6 [pii]
AID - 10.1007/s11845-023-03476-6 [doi]
PST - ppublish
SO  - Ir J Med Sci. 2024 Apr;193(2):769-775. doi: 10.1007/s11845-023-03476-6. Epub 2023 
      Aug 2.