PMID- 37529333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230918
IS  - 1759-720X (Print)
IS  - 1759-7218 (Electronic)
IS  - 1759-720X (Linking)
VI  - 15
DP  - 2023
TI  - A prognostic immune nutritional index can predict all-cause mortality in patients 
      with antineutrophil cytoplasmic antibody-associated vasculitis.
PG  - 1759720X231188818
LID - 10.1177/1759720X231188818 [doi]
LID - 1759720X231188818
AB  - BACKGROUND: Studies have proposed that nutritional and immune-related markers are 
      relevant with patient outcomes of various medical conditions and could be a 
      useful indicator of patient prognostication. OBJECTIVES: This study investigated 
      whether a prognostic immune nutritional index (PINI) at diagnosis could predict 
      adverse clinical outcomes in patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). DESIGN: A retrospective, single-centre 
      observational cohort analysis of patients with AAV. METHODS: All-cause mortality 
      and end-stage renal disease (ESRD) were investigated outcomes during the 
      observation period. PINI was calculated by serum albumin (g/mL) x 0.9 - monocyte 
      count (/mm(3)) x 0.0007, and the optimal cut-off of PINI was obtained using a 
      Youden index-based bootstrapping method. Cox hazard analyses were performed to 
      identify independent predictors of patient outcomes. RESULTS: Of the 250 eligible 
      patients, the median age of patients was 60.0 years, and 34.0% were men. During 
      the disease course, 33 (13.2%) died and 42 (16.8%) developed ESRD, respectively. 
      The ideal PINI cut-offs for all-cause mortality and ESRD were set as ⩽2.47 and 
      ⩽3.12 (sensitivity and specificity of 75.1% and 60.6% for mortality and 46.2% and 
      78.6% for ESRD). AAV patients with PINI ⩽2.47 and those with PINI ⩽3.12 exhibited 
      significantly higher rates for all-cause mortality and ESRD compared to those 
      with PINI >2.47 and >3.12. In the multivariable Cox analysis, PINI ⩽2.47 (hazard 
      ratio [HR]: 3.173, 95% confidence interval [CI]: 1.129, 8.916, p = 0.029) was 
      independently associated with all-cause patient mortality; however, PINI ⩽3.12 
      was not independently associated with ESRD (HR: 1.097, 95% CI: 0.419, 2.870, 
      p = 0.850). CONCLUSION: Findings from this study demonstrated PINI could predict 
      all-cause patient mortality in AAV, and a higher clinical attention is warranted 
      in those with PINI ⩽2.47 at initial diagnosis.
CI  - (c) The Author(s), 2023.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AUID- ORCID: 0000-0002-9002-9880
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Pyo, Jung Yoon
AU  - Pyo JY
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of 
      Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230729
PL  - England
TA  - Ther Adv Musculoskelet Dis
JT  - Therapeutic advances in musculoskeletal disease
JID - 101517322
PMC - PMC10387778
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody
OT  - end-stage renal disease
OT  - mortality
OT  - prognostic immune nutritional index
OT  - vasculitis
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/08/02 06:43
MHDA- 2023/08/02 06:44
PMCR- 2023/07/29
CRDT- 2023/08/02 03:54
PHST- 2023/01/25 00:00 [received]
PHST- 2023/06/28 00:00 [accepted]
PHST- 2023/08/02 06:43 [pubmed]
PHST- 2023/08/02 06:44 [medline]
PHST- 2023/08/02 03:54 [entrez]
PHST- 2023/07/29 00:00 [pmc-release]
AID - 10.1177_1759720X231188818 [pii]
AID - 10.1177/1759720X231188818 [doi]
PST - epublish
SO  - Ther Adv Musculoskelet Dis. 2023 Jul 29;15:1759720X231188818. doi: 
      10.1177/1759720X231188818. eCollection 2023.