PMID- 37529531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230803
IS  - 2325-9671 (Print)
IS  - 2325-9671 (Electronic)
IS  - 2325-9671 (Linking)
VI  - 11
IP  - 7
DP  - 2023 Jul
TI  - Effect of Autologous Conditioned Plasma Injections in Patients With Knee 
      Osteoarthritis.
PG  - 23259671231184848
LID - 10.1177/23259671231184848 [doi]
LID - 23259671231184848
AB  - BACKGROUND: Autologous conditioned plasma (ACP) is a commercially available 
      platelet concentrate with promising results from clinical trials. PURPOSE: To 
      evaluate the clinical outcome after 3 consecutive injections of ACP in patients 
      with knee osteoarthritis (OA) and study the influence of ACP composition and 
      different patient factors as predictors of treatment effect. STUDY DESIGN: Case 
      series; Level of evidence, 4. METHODS: This prospective case series included 260 
      patients (307 knees) who received ACP treatment for knee OA. The mean patient age 
      was 51 +/- 10 years. Improvement up to 12 months' follow-up was measured using the 
      Knee injury and Osteoarthritis Outcome Score (KOOS). ACP composition was analyzed 
      in 100 patients. The predictive value of age, sex, history of knee trauma, 
      Kellgren-Lawrence OA grade, body mass index, and ACP composition was evaluated 
      using generalized estimating equations. RESULTS: The mean overall KOOS improved 
      from 38 +/- 14 at baseline to 45 +/- 18 at 3 months, 45 +/- 18 at 6 months, and 43 +/- 18 
      at 12 months (all P < .05); 40% of patients achieved an improvement above the 
      minimal clinically important difference (MCID) of 8 after 6 months and 33% after 
      12 months. The variation in ACP composition did not correlate with KOOS (P > 
      .05). Older age led to a greater clinical benefit (beta = 0.27; P = .05), whereas 
      bilateral treatment predicted worse outcomes (beta = -5.6; P < .05). CONCLUSION: The 
      improvement in KOOS after treatment with ACP did not reach the MCID in most study 
      patients. Older age was a predictor for better outcomes. The composition of ACP 
      varied between patients but did not predict outcomes within the evaluated range. 
      The study findings show the limited benefit of ACP treatment for knee OA and call 
      for caution with routine use in clinical practice.
CI  - (c) The Author(s) 2023.
FAU - Korpershoek, Jasmijn V
AU  - Korpershoek JV
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Vonk, Lucienne A
AU  - Vonk LA
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Filardo, Giuseppe
AU  - Filardo G
AD  - Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, 
      Switzerland.
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, Lugano, 
      Switzerland.
FAU - Kester, Esmee C
AU  - Kester EC
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - van Egmond, Nienke
AU  - van Egmond N
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Saris, Daniel B F
AU  - Saris DBF
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
AD  - Department of Orthopedic Surgery and Sports Medicine, Mayo Clinic, Rochester, 
      Minnesota, USA.
AD  - Department of Reconstructive Medicine, University of Twente, Enschede, the 
      Netherlands.
FAU - Custers, Roel J H
AU  - Custers RJH
AD  - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20230728
PL  - United States
TA  - Orthop J Sports Med
JT  - Orthopaedic journal of sports medicine
JID - 101620522
PMC - PMC10387782
OTO - NOTNLM
OT  - ACP
OT  - PRP
OT  - injections
OT  - knee osteoarthritis
OT  - platelets
COIS- One or more of the authors has declared the following potential conflict of 
      interest or source of funding: This research was supported by the Dutch Arthritis 
      Foundation (grant No. LLP-12). AOSSM checks author disclosures against the Open 
      Payments Database (OPD). AOSSM has not conducted an independent investigation on 
      the OPD and disclaims any liability or responsibility relating thereto.
EDAT- 2023/08/02 06:42
MHDA- 2023/08/02 06:43
PMCR- 2023/07/28
CRDT- 2023/08/02 03:58
PHST- 2023/02/27 00:00 [received]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/08/02 06:43 [medline]
PHST- 2023/08/02 06:42 [pubmed]
PHST- 2023/08/02 03:58 [entrez]
PHST- 2023/07/28 00:00 [pmc-release]
AID - 10.1177_23259671231184848 [pii]
AID - 10.1177/23259671231184848 [doi]
PST - epublish
SO  - Orthop J Sports Med. 2023 Jul 28;11(7):23259671231184848. doi: 
      10.1177/23259671231184848. eCollection 2023 Jul.