PMID- 37530803
OWN - NLM
STAT- MEDLINE
DCOM- 20230824
LR  - 20230928
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 201
IP  - 4
DP  - 2023 Aug
TI  - Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary 
      Fibrosis: A Two-Sample Mendelian Randomization Study.
PG  - 355-362
LID - 10.1007/s00408-023-00640-8 [doi]
AB  - PURPOSE: The causal relationships between circulating adipokines and idiopathic 
      pulmonary fibrosis (IPF) are yet to be established. We performed a two-sample 
      Mendelian randomization (MR) study to investigate the causal roles of adipokines 
      on IPF risk. METHODS: We analyzed the summary data from genome-wide association 
      studies (GWAS), including adiponectin, leptin, resistin and monocyte 
      chemoattractant protein-1 (MCP-1) and IPF. The inverse-variance weighted (IVW) 
      method was considered as the major method and the MR-Egger, weighted median, 
      simple mode and weighted mode were utilized as complementary methods. We also 
      performed the sensitivity analyses, including heterogeneity test, horizontal 
      pleiotropy test and leave-one-out analysis. RESULTS: The selected number of 
      single nucleotide polymorphisms (SNPs) was 13 for adiponectin, 6 for leptin,12 
      for resistin, and 6 for MCP-1, respectively. The results showed a causal effect 
      of the circulating adiponectin levels on the risk of IPF (OR 0.645, 95% CI 
      0.457-0.911, P = 0.013). However, we did not observe significant associations of 
      genetic changes in serum leptin (OR 1.018, 95% CI 0.442-2.346, P = 0.967), 
      resistin (OR 1.002, 95% CI 0.712-1.408, P = 0.993), and MCP-1 (OR 1.358, 95% CI 
      0.891-2.068, P = 0.155) with risk of developing IPF. There was no evidence of 
      heterogeneity or horizontal pleiotropy. The sensitivity analyses confirmed that 
      our results were stable and reliable. CONCLUSIONS: The increase in serum 
      adiponectin was associated causally with a decreased risk of developing IPF. 
      There is no evidence to support a causal association between leptin, resistin or 
      MCP-1 with risk of IPF. Further studies are needed to confirm our findings.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Huang, Dong
AU  - Huang D
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital, 
      Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
AD  - Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and 
      Immunology, NHC, West China Hospital, Sichuan University, No. 37 Guoxue Alley, 
      Chengdu, 610041, Sichuan, China.
FAU - Gong, Linjing
AU  - Gong L
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital, 
      Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
AD  - Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and 
      Immunology, NHC, West China Hospital, Sichuan University, No. 37 Guoxue Alley, 
      Chengdu, 610041, Sichuan, China.
FAU - Wu, Zhenru
AU  - Wu Z
AD  - Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and 
      Immunology, NHC, West China Hospital, Sichuan University, No. 37 Guoxue Alley, 
      Chengdu, 610041, Sichuan, China.
FAU - Shi, Yujun
AU  - Shi Y
AD  - Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and 
      Immunology, NHC, West China Hospital, Sichuan University, No. 37 Guoxue Alley, 
      Chengdu, 610041, Sichuan, China. shiyujun@scu.edu.cn.
FAU - Liang, Zongan
AU  - Liang Z
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital, 
      Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. 
      liangza@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230802
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - 0 (Adipokines)
RN  - 0 (Resistin)
RN  - 0 (Leptin)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Humans
MH  - *Adipokines
MH  - Resistin/genetics
MH  - Leptin/genetics
MH  - Adiponectin/genetics
MH  - Genome-Wide Association Study
MH  - Mendelian Randomization Analysis
MH  - *Idiopathic Pulmonary Fibrosis/genetics
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Adipokines
OT  - Adiponectin
OT  - Idiopathic pulmonary fibrosis
OT  - Mendelian randomization
EDAT- 2023/08/02 13:08
MHDA- 2023/08/24 06:42
CRDT- 2023/08/02 11:04
PHST- 2023/05/23 00:00 [received]
PHST- 2023/07/25 00:00 [accepted]
PHST- 2023/08/24 06:42 [medline]
PHST- 2023/08/02 13:08 [pubmed]
PHST- 2023/08/02 11:04 [entrez]
AID - 10.1007/s00408-023-00640-8 [pii]
AID - 10.1007/s00408-023-00640-8 [doi]
PST - ppublish
SO  - Lung. 2023 Aug;201(4):355-362. doi: 10.1007/s00408-023-00640-8. Epub 2023 Aug 2.