PMID- 37531437
OWN - NLM
STAT- MEDLINE
DCOM- 20230804
LR  - 20230921
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 9
IP  - 31
DP  - 2023 Aug 2
TI  - Cross-scale tracing of nanoparticles and tumors at the single-cell level using 
      the whole-lung atlas.
PG  - eadh7779
LID - 10.1126/sciadv.adh7779 [doi]
LID - eadh7779
AB  - Currently, the effectiveness of oncotherapy is limited by tumor heterogeneities, 
      which presents a huge challenge for the development of nanotargeted drug delivery 
      systems (DDSs). Therefore, it is important to resolve the spatiotemporal 
      interactions between tumors and nanoparticles. However, targeting evaluation has 
      been limited by particle visualization due to the gap between whole-organ scale 
      and subcellular precision. Here, a high-precision three-dimensional (3D) 
      visualization of tumor structure based on the micro-optical sectioning tomography 
      (MOST) system and fluorescence MOST (fMOST) system is presented to clarify 3D 
      spatial distribution of nanoparticles within the tumor. We demonstrate that 
      through the MOST/fMOST system, it is possible to reveal multidimensional and 
      cross-scale correlations between the tumor structure and nanoparticle 
      distribution to remodel the tumor microenvironment and explore the structural 
      parameters of vasculature. This visualization methodology provides an accurate 
      assessment of the efficacy, distribution, and targeting efficiency of DDSs for 
      oncotherapy compared to available approaches.
FAU - Cao, Zeying
AU  - Cao Z
AUID- ORCID: 0000-0001-9091-8621
AD  - Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese 
      Academy of Sciences, Shanghai 201203, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Zhao, Yanli
AU  - Zhao Y
AD  - Lingang Laboratory, Shanghai 201602, China.
FAU - Sun, Hongyu
AU  - Sun H
AD  - Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese 
      Academy of Sciences, Shanghai 201203, China.
FAU - Sun, Xian
AU  - Sun X
AD  - Center for MOST and Image Fusion Analysis, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201210, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Center for MOST and Image Fusion Analysis, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201210, China.
FAU - Zhang, Shuo
AU  - Zhang S
AD  - Lingang Laboratory, Shanghai 201602, China.
FAU - Wang, Caifen
AU  - Wang C
AD  - Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese 
      Academy of Sciences, Shanghai 201203, China.
FAU - Xiong, Ting
AU  - Xiong T
AD  - Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese 
      Academy of Sciences, Shanghai 201203, China.
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Naeem, Abid
AU  - Naeem A
AD  - Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi 
      University of Traditional Chinese Medicine, Nanchang, 330004, China.
FAU - Zhang, Jiwen
AU  - Zhang J
AUID- ORCID: 0000-0003-0410-0052
AD  - Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese 
      Academy of Sciences, Shanghai 201203, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
AD  - Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi 
      University of Traditional Chinese Medicine, Nanchang, 330004, China.
AD  - NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical 
      Excipients, National Institutes for Food and Drug Control, Beijing 100050, China.
FAU - Yin, Xianzhen
AU  - Yin X
AUID- ORCID: 0000-0002-7870-1718
AD  - Lingang Laboratory, Shanghai 201602, China.
AD  - Center for MOST and Image Fusion Analysis, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201210, China.
LA  - eng
PT  - Journal Article
DEP - 20230802
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
SB  - IM
MH  - Humans
MH  - *Neoplasms
MH  - *Nanoparticles/chemistry
MH  - Drug Delivery Systems/methods
MH  - Lung/diagnostic imaging
MH  - *Tomography, Optical/methods
MH  - Tumor Microenvironment
PMC - PMC10396308
EDAT- 2023/08/02 19:15
MHDA- 2023/08/04 06:43
PMCR- 2023/08/02
CRDT- 2023/08/02 14:03
PHST- 2023/08/04 06:43 [medline]
PHST- 2023/08/02 19:15 [pubmed]
PHST- 2023/08/02 14:03 [entrez]
PHST- 2023/08/02 00:00 [pmc-release]
AID - adh7779 [pii]
AID - 10.1126/sciadv.adh7779 [doi]
PST - ppublish
SO  - Sci Adv. 2023 Aug 2;9(31):eadh7779. doi: 10.1126/sciadv.adh7779. Epub 2023 Aug 2.