PMID- 37533396
OWN - NLM
STAT- MEDLINE
DCOM- 20231110
LR  - 20240126
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 14
IP  - 4
DP  - 2023 Dec
TI  - Minced Cartilage Implantation in Acetabular Cartilage Defects: Case Series with 
      2-Year Results.
PG  - 393-399
LID - 10.1177/19476035231189840 [doi]
AB  - OBJECTIVE: The objective was to evaluate clinical outcome and safety of 
      arthroscopic, autologous minced cartilage implantation for acetabular cartilage 
      lesions observed during hip arthroscopy to treat femoroacetabular impingement 
      syndrome (FAIS). DESIGN: Eleven male patients, average age: 29.4 +/- 5.4 years, 
      average body mass index (BMI): 24.2 +/- 2.2 kg/m(2), scheduled for hip arthroscopy 
      due to FAIS accompanied by an acetabular cartilage lesion were included in the 
      case series. Cartilage tissue was harvested and minced from the loose cartilage 
      flap at the chondrolabral lesion by arthroscopic shaver, augmented with 
      autologous conditioned plasma, implanted into the defect, and fixated by 
      autologous thrombin. Concomitant interventions were performed as indicated. The 
      patients were evaluated preoperatively and at 24-month follow-up, using the 
      International Hip Outcome Tool-12 (iHOT-12) and Visual Analog Scale (VAS) pain 
      score and by magnetic resonance imaging (MRI) using the Magnetic Resonance 
      Observation of Cartilage Repair Tissue (MOCART) grading scale at the 2-year 
      follow-up. RESULTS: The defect size was on average 3.5 cm(2) (1.5-4.5 cm(2)). 
      From preoperatively to 2 years postoperatively, the iHOT-12 significantly 
      improved from 50.2 +/- 18 to 86.5 +/- 19 (P < 0.0001), and pain score decreased from 
      5.6 +/- 1.8 to 1.0 +/- 1.5 (P < 0.0001) on the Visual Analog Scale pain score. 
      Regarding functional outcome and pain, 10 of the 11 patients and all patients 
      reached the minimal clinically important difference (MCID), respectively. The 
      postoperative average MOCART score was 87.2 (+/- 9.2). No adverse events or 
      reoperations were observed. CONCLUSIONS: Arthroscopic, autologous minced 
      cartilage implantation for treating full-thickness acetabular cartilage lesions 
      in FAIS shows statistically and clinically significant improvement at short-term 
      follow-up.
FAU - Gebhardt, Sebastian
AU  - Gebhardt S
AD  - Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University 
      of Greifswald, Greifswald, Germany.
FAU - Hofer, Andre
AU  - Hofer A
AD  - Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University 
      of Greifswald, Greifswald, Germany.
FAU - Wassilew, Georgi I
AU  - Wassilew GI
AD  - Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University 
      of Greifswald, Greifswald, Germany.
FAU - Sobau, Christian
AU  - Sobau C
AD  - ARCUS Sportklinik, Pforzheim, Germany.
FAU - Zimmerer, Alexander
AU  - Zimmerer A
AUID- ORCID: 0000-0002-5195-7529
AD  - Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University 
      of Greifswald, Greifswald, Germany.
AD  - Orthopadische Klinik Paulinenhilfe, Diakonie-Klinikum Stuttgart, Stuttgart, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230803
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - Humans
MH  - Male
MH  - Young Adult
MH  - Adult
MH  - Follow-Up Studies
MH  - Cartilage/surgery
MH  - Acetabulum/surgery
MH  - *Cartilage Diseases/surgery
MH  - *Femoracetabular Impingement/diagnostic imaging/surgery
MH  - Pain
PMC - PMC10807734
OTO - NOTNLM
OT  - biomechanics
OT  - bone
OT  - cells
OT  - chondrocytes
OT  - in vivo
OT  - osteoarthritis disease modification
OT  - tissue
COIS- Declaration of Conflicting InterestsThe author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: A.Z. received personal fees from Arthrex. The other 
      authors report no conflict of interest.
EDAT- 2023/08/03 06:43
MHDA- 2023/11/10 06:45
PMCR- 2023/08/03
CRDT- 2023/08/03 03:39
PHST- 2023/11/10 06:45 [medline]
PHST- 2023/08/03 06:43 [pubmed]
PHST- 2023/08/03 03:39 [entrez]
PHST- 2023/08/03 00:00 [pmc-release]
AID - 10.1177_19476035231189840 [pii]
AID - 10.1177/19476035231189840 [doi]
PST - ppublish
SO  - Cartilage. 2023 Dec;14(4):393-399. doi: 10.1177/19476035231189840. Epub 2023 Aug 
      3.