PMID- 37533572
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230804
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Dose-response relationship between multiple trace elements and risk of all-cause 
      mortality: a prospective cohort study.
PG  - 1205537
LID - 10.3389/fnut.2023.1205537 [doi]
LID - 1205537
AB  - OBJECTIVES: We aimed to prospectively investigate the independent and combined 
      relationship between trace elements concentrations [blood (selenium, manganese), 
      serum (copper, zinc), and urine (cobalt, molybdenum, tin, strontium, iodine)] and 
      all-cause mortality. METHODS: This study included 5,412 individuals with 
      demographical, examination, and laboratory data from the National Health and 
      Nutrition Examination Survey. Three statistical models, including Cox 
      proportional hazards models, restricted cubic spline models, and Bayesian kernel 
      machine regression (BKMR) models, were conducted to estimate the longitudinal 
      relationship between trace elements and all-cause mortality. RESULTS: There were 
      356 deaths documented with a median follow-up time of 70 months. In the 
      single-exposure model, the results showed that compared with the lowest quartile, 
      the adjusted hazard ratios (HRs) of mortality for the highest quartile of 
      selenium, manganese, and strontium were 0.47 (95% CI: 0.28-0.79), 1.57 (95% CI: 
      1.14-2.14), and 0.47 (95% CI: 0.26-0.86), respectively. A nonlinear relationship 
      between zinc, cobalt and mortality was also observed. Furthermore, a significant 
      overall effect of mixtures of trace elements on all-cause mortality was 
      identified, especially when the mixture was at the 60th percentile or lower. 
      CONCLUSION: The association of multiple trace elements with all-cause mortality 
      was identified in this study. It is recommended that healthcare providers and 
      relevant public health agencies should strengthen the surveillance and management 
      of trace elements. Emphasis should be placed on monitoring the sources of trace 
      elements such as the body, food, and environment. More population studies and 
      animal experiments should be conducted to identify the underlying mechanisms.
CI  - Copyright (c) 2023 Zhao, Wang, Yang and Shen.
FAU - Zhao, Shaohua
AU  - Zhao S
AD  - Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, 
      China.
AD  - Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital 
      of Shandong University, Jinan, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Internal Medicine, Jinan Hospital, Jinan, China.
FAU - Yang, Xiaorong
AU  - Yang X
AD  - Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China.
AD  - Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College 
      of Medicine, Shandong University, Jinan, China.
FAU - Shen, Lin
AU  - Shen L
AD  - Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, 
      China.
AD  - Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital 
      of Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
DEP - 20230718
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10391637
OTO - NOTNLM
OT  - dose-response
OT  - epidemiology
OT  - mixtures
OT  - mortality
OT  - trace element
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/03 06:42
MHDA- 2023/08/03 06:43
PMCR- 2023/01/01
CRDT- 2023/08/03 03:53
PHST- 2023/04/14 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/08/03 06:43 [medline]
PHST- 2023/08/03 06:42 [pubmed]
PHST- 2023/08/03 03:53 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1205537 [doi]
PST - epublish
SO  - Front Nutr. 2023 Jul 18;10:1205537. doi: 10.3389/fnut.2023.1205537. eCollection 
      2023.