PMID- 37535916
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 29
IP  - 7
DP  - 2023 Oct
TI  - Diagnostic Value of cTnl, NT-pro BNP, and Combined Tests in Acute Myocardial 
      Infarction Patients.
PG  - 412-417
LID - AT8663 [pii]
AB  - OBJECTIVE: Acute myocardial infarction (AMI) is characterized by heart damage 
      resulting from blocked blood flow. Prompt diagnosis is vital for timely treatment 
      and saving lives. This study aimed to evaluate the diagnostic value of cTnl, 
      NT-pro BNP, and a combined test in AMI patients. METHODS: In this study, a 
      retrospective observational design was employed, and we selected 221 patients 
      with AMI admitted to our hospital within a 3-year period as the research subjects 
      and included them in the AMI group. Additionally, 200 patients from the control 
      group, who visited our hospital for physical examinations, were selected to 
      compare the expressions of cardiac Troponin I (cTnl) and N-Terminal pro-B-type 
      Natriuretic Peptide (NT-pro BNP) between the two groups. Receiver Operating 
      Characteristic (ROC) curves were constructed to analyze the diagnostic value of 
      cTnl combined with NT-pro BNP for AMI. Furthermore, AMI patients were categorized 
      into four groups based on the New York Heart Association (NYHA) classification 
      (grades I, II, III, and IV). The differences in cTnl, NT-pro BNP, and Left 
      Ventricular Ejection Fraction (LVEF) were compared among the AMI patients with 
      different cardiac function grades to analyze their correlation and diagnostic 
      value in assessing the severity of AMI-related cardiac insufficiency. RESULTS: 
      The levels of cTnl and NT-pro BNP in AMI patients were significantly higher than 
      those in the control group, and their combined detection effectively facilitated 
      the diagnosis of AMI occurrence. Moreover, cTnl and NT-pro BNP concentrations 
      increased with the severity of cardiac dysfunction (NYHA grades) and showed a 
      notable negative correlation with LVEF. Furthermore, the combined testing of cTnl 
      and NT-pro BNP demonstrated significant value in evaluating the severity of AMI 
      in patients. CONCLUSIONS: The combined detection of cTnl and NT-pro BNP holds 
      considerable application value in diagnosing AMI occurrence and assessing its 
      severity.
FAU - Shi, Junhui
AU  - Shi J
FAU - Wang, Wei
AU  - Wang W
FAU - Sun, Yongfang
AU  - Sun Y
FAU - Zhou, Minzhi
AU  - Zhou M
FAU - Liu, Jiang
AU  - Liu J
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Natriuretic Peptide, Brain
MH  - Stroke Volume/physiology
MH  - Retrospective Studies
MH  - Ventricular Function, Left
MH  - *Myocardial Infarction/diagnostic imaging
MH  - Biomarkers
EDAT- 2023/08/03 19:14
MHDA- 2023/10/23 12:42
CRDT- 2023/08/03 16:33
PHST- 2023/10/23 12:42 [medline]
PHST- 2023/08/03 19:14 [pubmed]
PHST- 2023/08/03 16:33 [entrez]
AID - AT8663 [pii]
PST - ppublish
SO  - Altern Ther Health Med. 2023 Oct;29(7):412-417.