PMID- 3754037
OWN - NLM
STAT- MEDLINE
DCOM- 19860403
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 42
IP  - 3
DP  - 1986
TI  - Male-female difference in synaptic organization of the ventromedial nucleus of 
      the hypothalamus in the rat.
PG  - 232-6
AB  - The ventromedial nucleus of the hypothalamus (VMN) of male and female rats was 
      examined ultrastructurally at 100 days of age. Axodendritic shaft and spine 
      synapses were counted in two subdivisions of the nucleus, the dorsomedial part 
      (DM-VMN), which contains only a few sex steroid-concentrating neurons, and the 
      ventrolateral part (VL-VMN), which is abundant in such neurons. In normal males, 
      the numbers of shaft and spine synapses were significantly greater in the VL-VMN 
      than in the DM-VMN. In normal females, however, there was no significant 
      difference in the numbers of shaft and spine synapses between the DM-VMN and the 
      VL-VMN. Moreover, the numbers of shaft and spine synapses in the VL-VMN were 
      significantly greater in normal males than in normal females. Castration of males 
      on day 1 significantly reduced the numbers of shaft and spine synapses in the 
      VL-VMN to the level comparable to those of normal females. In contrast, neonatal 
      treatment of females with 1.25 mg testosterone propionate (TP) on day 5 
      significantly increased the numbers of shaft and spine synapses to the levels 
      comparable to those of normal males. In the DM-VMN, there were no significant 
      differences in the numbers of shaft and spine synapses among normal and 
      experimental animals. These results suggest that the synaptic organization in the 
      VMN is sexually dimorphic but the occurrence of this structural difference is 
      limited to the VL-VMN which is abundant in sex steroid receptors, and is modified 
      by neonatal sex steroid environment.
FAU - Matsumoto, A
AU  - Matsumoto A
FAU - Arai, Y
AU  - Arai Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Androgens)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Androgens/*physiology
MH  - Animals
MH  - Axons/ultrastructure
MH  - Dendrites/ultrastructure
MH  - Female
MH  - Male
MH  - Neuronal Plasticity
MH  - Orchiectomy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Sex Characteristics
MH  - Synapses/ultrastructure
MH  - Testosterone/pharmacology
MH  - Ventromedial Hypothalamic Nucleus/growth & development/*ultrastructure
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1159/000124445 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1986;42(3):232-6. doi: 10.1159/000124445.