PMID- 37540643
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20231122
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 46
IP  - 11
DP  - 2023 Nov
TI  - Nomogram for predicting coronary artery lesions in patients with Kawasaki 
      disease.
PG  - 1434-1441
LID - 10.1002/clc.24113 [doi]
AB  - BACKGROUND: Coronary artery lesions are the most important complications of 
      Kawasaki disease. Approximately 25-30% of untreated patients develop coronary 
      artery disease, which can lead to long-term cardiovascular sequelae. AIM: The aim 
      of this study is to evaluate the risk factors for coronary artery lesions in 
      Kawasaki disease and to construct a nomogram for predicting the likelihood of 
      developing such lesions. METHODS: Data from 599 patients between January 2012 and 
      June 2020 were reviewed retrospectively. Patients were randomly assigned to the 
      training set (n = 450) and the validation set (n = 149). A comparison of clinical 
      features and laboratory data was performed, followed by multivariate logistic 
      regression analysis to identify independent risk factors and develop the 
      nomogram. The predictive efficiency of the nomogram was evaluated using the 
      calibration curve, area under the receiver operating characteristic curve (AUC), 
      C-index, and decision curve analysis (DCA). RESULTS: Intravenous immunoglobulin 
      (IVIG) resistance, delayed IVIG treatment, C-reactive protein, and 
      neutrophil/lymphocyte ratio were identified as independent risk factors for the 
      development of coronary artery lesions. The nomogram was constructed based on 
      these four variables. The calibration curve of the nomogram showed a high degree 
      of agreement between the predicted probability and the actual probability. The 
      AUC of the nomogram in the training and validation set was 0.790 and 0.711, 
      respectively. In addition, DCA revealed that the nomogram provided a significant 
      net benefit, further supporting its clinical utility. CONCLUSIONS: The 
      constructed nomogram demonstrates a strong and reliable performance in predicting 
      coronary artery lesions, which enables clinicians to make timely and tailored 
      clinical decisions.
CI  - (c) 2023 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Yue, Yang-Hua
AU  - Yue YH
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Infectious Diseases, Youxian People's Hospital, Zhuzhou, China.
FAU - Xie, Tian
AU  - Xie T
AD  - Department of Pediatrics, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Peng, Jian-Qiao
AU  - Peng JQ
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Deng, Zhong-Hua
AU  - Deng ZH
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
FAU - Cao, You-de
AU  - Cao YD
AUID- ORCID: 0009-0009-2078-5822
AD  - Department of Clinical Laboratory, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20230804
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Humans
MH  - *Coronary Artery Disease/diagnosis/etiology
MH  - Coronary Vessels/diagnostic imaging
MH  - Immunoglobulins, Intravenous/pharmacology
MH  - *Mucocutaneous Lymph Node Syndrome/complications/diagnosis
MH  - Nomograms
MH  - Retrospective Studies
PMC - PMC10642325
OTO - NOTNLM
OT  - Kawasaki disease
OT  - coronary artery lesions
OT  - nomogram
OT  - risk factor
EDAT- 2023/08/04 19:15
MHDA- 2023/11/14 06:43
PMCR- 2023/08/04
CRDT- 2023/08/04 13:23
PHST- 2023/07/20 00:00 [revised]
PHST- 2023/03/13 00:00 [received]
PHST- 2023/07/27 00:00 [accepted]
PHST- 2023/11/14 06:43 [medline]
PHST- 2023/08/04 19:15 [pubmed]
PHST- 2023/08/04 13:23 [entrez]
PHST- 2023/08/04 00:00 [pmc-release]
AID - CLC24113 [pii]
AID - 10.1002/clc.24113 [doi]
PST - ppublish
SO  - Clin Cardiol. 2023 Nov;46(11):1434-1441. doi: 10.1002/clc.24113. Epub 2023 Aug 4.