PMID- 37542856
OWN - NLM
STAT- MEDLINE
DCOM- 20230817
LR  - 20230817
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 165
DP  - 2023 Sep
TI  - Phytochemicals for the treatment of metabolic diseases: Evidence from clinical 
      studies.
PG  - 115274
LID - S0753-3322(23)01065-X [pii]
LID - 10.1016/j.biopha.2023.115274 [doi]
AB  - With the continuous improvement of people's living standard, the incidence of 
      metabolic diseases is gradually increasing in recent years. There is growing 
      interest in finding drugs to treat metabolic diseases from natural compounds due 
      to their good efficacy and limited side effects. Over the past few decades, many 
      phytochemicals derived from natural plants, such as berberine, curcumin, 
      quercetin, resveratrol, rutin, and hesperidin, have been shown to have good 
      pharmacological activity against metabolic diseases in preclinical studies. More 
      importantly, clinical trials using these phytochemicals to treat metabolic 
      diseases have been increasing. This review comprehensively summarizes the 
      clinical progress of phytochemicals derived from natural plants in the treatment 
      of several metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity 
      and non-alcoholic fatty liver disease (NAFLD). Accumulating clinical evidence 
      shows that a total of 18 phytochemicals have good therapeutic effects on the 
      three metabolic diseases by lowering blood glucose and lipid levels, reducing 
      insulin resistance, enhancing insulin sensitivity, increasing energy expenditure, 
      improving liver function, and relieving inflammation and oxidative stress. The 
      information will help us better understand the medicinal value of these 
      phytochemicals and promote their clinical application in the treatment of 
      metabolic diseases.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Luo, Yuting
AU  - Luo Y
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Zeng, Yujiao
AU  - Zeng Y
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Peng, Jiayan
AU  - Peng J
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Zhang, Kun
AU  - Zhang K
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Wang, Lijie
AU  - Wang L
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Feng, Tu
AU  - Feng T
AD  - School of Ecological Engineering, Guizhou University of Engineering Science, 
      Bijie 551700, China. Electronic address: plantbiology@126.com.
FAU - Nhamdriel, Tsedien
AU  - Nhamdriel T
AD  - Department of Tibetan medicine, University of Tibetan Medicine, Lhasa 850000, 
      China. Electronic address: 536913114@qq.com.
FAU - Fan, Gang
AU  - Fan G
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China; Meishan Hospital of Chengdu University of 
      Traditional Chinese Medicine, Meishan 620010, China. Electronic address: 
      fangang1111@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230803
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Phytochemicals)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Non-alcoholic Fatty Liver Disease/metabolism
MH  - *Insulin Resistance
MH  - Obesity/drug therapy
MH  - Phytochemicals/therapeutic use
OTO - NOTNLM
OT  - Clinical evidence
OT  - Diabetes
OT  - Nonalcoholic fatty liver disease
OT  - Obesity
OT  - Phytochemicals
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/06 05:42
MHDA- 2023/08/17 06:43
CRDT- 2023/08/05 18:05
PHST- 2023/06/12 00:00 [received]
PHST- 2023/07/29 00:00 [revised]
PHST- 2023/07/31 00:00 [accepted]
PHST- 2023/08/17 06:43 [medline]
PHST- 2023/08/06 05:42 [pubmed]
PHST- 2023/08/05 18:05 [entrez]
AID - S0753-3322(23)01065-X [pii]
AID - 10.1016/j.biopha.2023.115274 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2023 Sep;165:115274. doi: 10.1016/j.biopha.2023.115274. Epub 
      2023 Aug 3.