PMID- 37543952
OWN - NLM
STAT- MEDLINE
DCOM- 20230808
LR  - 20230809
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Dec
TI  - Effects of pre-sleep protein supplementation on plasma markers of muscle damage 
      and inflammatory cytokines resulting from sprint interval training in trained 
      swimmers.
PG  - 2244478
LID - 10.1080/15502783.2023.2244478 [doi]
LID - 2244478
AB  - BACKGROUND: Pre-sleep protein has been shown to improve muscle recovery overnight 
      following exercise-induced muscle damage. Whether such an approach affects 
      recovery from sprint interval training (SIT) has yet to be elucidated. This study 
      examined the effects of protein supplementation every night before sleep on early 
      (45 min post-SIT) and late (24 and 48 h after SIT) responses of creatine kinase 
      (CK) and inflammatory cytokines, including interleukin-6 and 10 (IL-6 and IL-10) 
      and tumor necrosis factor-alpha (TNFalpha). METHODS: Twenty trained swimmers 
      underwent a 2-week in-water swimming SIT (two sets of 12 x 50-m all-out swims, 
      interspersed by 1:1 recovery between each sprint and 3 min of rest between sets) 
      and were randomized to two intervention groups receiving either 0.5 g kg(-1) 
      day(-1) protein beverage (PRO) or the same amount of carbohydrate (CHO) preceding 
      going to bed every night. For initial and final training sessions, CK and 
      cytokine responses were analyzed at different time points, including resting, 
      immediately after completion, 45 min post-SIT, and 24 and 48 h after SIT. 
      RESULTS: CK concentrations elevated from resting point to 24 and 48 h post-SIT 
      for both PRO and CHO groups (p < 0.05). In both training groups, the peak levels 
      of IL-6 and 10 were observed 45 min post-SIT on both occasions. TNFalpha levels 
      significantly elevated from rest to immediately after SIT (p < 0.001) and 
      returned to values equivalent to the baseline afterward in both groups and on 
      both occasions. In both groups, swimming SIT also switched the cytokine response 
      48 hours after exercise to an anti-inflammatory status by decreasing the ratio of 
      IL-6 to IL-10 (p < 0.04) in the last training session. CONCLUSIONS: Pre-sleep 
      protein ingestion failed to ameliorate blood markers of muscle damage. The late 
      anti-inflammatory profile of cytokines and exercise-induced muscle damage 
      improved after two weeks of swimming SIT with either protein or carbohydrate 
      ingestion before sleep.
FAU - Wu, Cairong
AU  - Wu C
AUID- ORCID: 0009-0007-3839-8543
AD  - Zhengde Polytechnic College, Department of Public Education, Nanjing, Jiangsu, 
      China.
AD  - Adamson University, Graduate School, Metro Manila, Philippines.
FAU - Deng, Jie
AU  - Deng J
AUID- ORCID: 0009-0008-6944-0086
AD  - Nanjing University of Aeronautics and Astronautics, Department of Physical 
      Education, Nanjing, Jiangsu, China.
FAU - Gao, Chengli
AU  - Gao C
AUID- ORCID: 0009-0006-2054-5907
AD  - Sanjiang University, Department of Physical Education, Nanjing, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
RN  - 0 (Cytokines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Carbohydrates)
SB  - IM
MH  - Humans
MH  - *Cytokines
MH  - Interleukin-10
MH  - *High-Intensity Interval Training
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Dietary Supplements
MH  - Swimming
MH  - Anti-Inflammatory Agents
MH  - Sleep
MH  - Carbohydrates/pharmacology
MH  - Muscles
MH  - Muscle, Skeletal
PMC - PMC10405750
OTO - NOTNLM
OT  - Intermittent exercise
OT  - conditioning
OT  - cytokine
OT  - dietary protein
OT  - muscle damage
OT  - supplement
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2023/08/06 19:15
MHDA- 2023/08/08 06:42
PMCR- 2023/08/06
CRDT- 2023/08/06 14:46
PHST- 2023/08/08 06:42 [medline]
PHST- 2023/08/06 19:15 [pubmed]
PHST- 2023/08/06 14:46 [entrez]
PHST- 2023/08/06 00:00 [pmc-release]
AID - 2244478 [pii]
AID - 10.1080/15502783.2023.2244478 [doi]
PST - ppublish
SO  - J Int Soc Sports Nutr. 2023 Dec;20(1):2244478. doi: 
      10.1080/15502783.2023.2244478.