PMID- 37544425
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240202
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 165
IP  - 1
DP  - 2024 Jan
TI  - The Subglottic Stenosis 6 Questionnaire: A Novel Quality-of-Life Survey Validated 
      to Predict Need for Intervention in Patients With Idiopathic Subglottic Stenosis.
PG  - 161-171
LID - S0012-3692(23)05254-6 [pii]
LID - 10.1016/j.chest.2023.07.4217 [doi]
AB  - BACKGROUND: Idiopathic subglottic stenosis (iSGS) is a recurrent, chronic disease 
      defined by fibroinflammatory narrowing of the subglottic airway. A key challenge 
      in treatment is monitoring disease progression, which may be debilitating and 
      unpredictable in its timing. RESEARCH QUESTION: Can the Subglottic Stenosis 6 
      (SGS-6) questionnaire be validated as a novel quality-of-life (QOL) instrument to 
      monitor breathing, disease progression, and disease severity proactively in 
      patients with iSGS? STUDY DESIGN AND METHODS: Panel data from 51 patients with 
      iSGS were collected from January 2012 through June 2022, representing 1,684 
      patient encounters including routine office visits and treatment encounters. 
      Subjective QOL scores (including the novel SGS-6 and established RAND-36 and 
      EuroQol Five Dimensions [EQ-5D] Visual Analog Scale) and objective pulmonary 
      function test (PFT) results were collected at each visit. Subjective SGS-6 QOL 
      scores were repeated within 1 week of initial reporting. Panel regression 
      analyses were performed to assess the relationship between SGS-6 scores, PFT 
      results, and a patient's need for intervention. Minimal clinically important 
      differences (MCIDs) for SGS-6 and peak expiratory flow percentage (PEF%) were 
      assessed using receiver operating characteristic (ROC) curve analysis and a 
      patient's need for intervention as the external anchor. RESULTS: Each one-point 
      increase in SGS-6 score (of a maximum of 27) was associated with a 3.26% decrease 
      in PEF%, a 1.93-point decrease in RAND-36 Physical Health composite score, a 
      1.27-point decrease in RAND-36 Mental Health composite score, and a 0.88-point 
      decrease in EQ-5D Visual Analog Scale score. The intracorrelation coefficient for 
      the SGS-6 composite score is 0.838 (95% CI, 0.770-0.888). Compared with patient 
      baselines, SGS-6 scores were 4.66 points greater at the time of intervention with 
      an MCID of 2.25 from a patient's baseline. The area under the ROC curve for SGS-6 
      and a patient's intervention point was 0.81. INTERPRETATION: iSGS disease 
      severity can be modeled using the SGS-6 questionnaire, offering physicians and 
      patients a potentially new method of tracking disease progression and need for 
      intervention remotely.
CI  - Copyright (c) 2023 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Lu, Richard J
AU  - Lu RJ
AD  - Harvard Medical School, Boston, MA.
FAU - Hijaz, Baraa
AU  - Hijaz B
AD  - Harvard Medical School, Boston, MA.
FAU - Naunheim, Matthew R
AU  - Naunheim MR
AD  - Harvard Medical School, Boston, MA; Mass Eye and Ear, Boston, MA; Massachusetts 
      General Hospital, Boston, MA.
FAU - Stevenson, Lily
AU  - Stevenson L
AD  - Mass Eye and Ear, Boston, MA.
FAU - Franco, Ramon A Jr
AU  - Franco RA Jr
AD  - Harvard Medical School, Boston, MA; Mass Eye and Ear, Boston, MA; Massachusetts 
      General Hospital, Boston, MA. Electronic address: ramon_franco@meei.harvard.edu.
LA  - eng
PT  - Journal Article
DEP - 20230806
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2024 Jan;165(1):7-8. PMID: 38199736
MH  - Humans
MH  - Constriction, Pathologic
MH  - *Quality of Life
MH  - *Laryngostenosis/diagnosis/therapy
MH  - Disease Progression
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - SGS-6
OT  - SILSI
OT  - awake serial intralesional steroid injections
OT  - fibroinflammatory narrowing
OT  - iSGS
OT  - idiopathic subglottic stenosis
OT  - laryngeal obstruction
OT  - minimum clinically important difference
OT  - panel regression
OT  - pulmonary function test
OT  - quality of life
OT  - subglottic airway
COIS- Financial/Nonfinancial Disclosures None declared.
EDAT- 2023/08/07 00:42
MHDA- 2024/01/12 06:42
CRDT- 2023/08/06 19:14
PHST- 2023/04/27 00:00 [received]
PHST- 2023/07/25 00:00 [revised]
PHST- 2023/07/28 00:00 [accepted]
PHST- 2024/01/12 06:42 [medline]
PHST- 2023/08/07 00:42 [pubmed]
PHST- 2023/08/06 19:14 [entrez]
AID - S0012-3692(23)05254-6 [pii]
AID - 10.1016/j.chest.2023.07.4217 [doi]
PST - ppublish
SO  - Chest. 2024 Jan;165(1):161-171. doi: 10.1016/j.chest.2023.07.4217. Epub 2023 Aug 
      6.