PMID- 37546961
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
DP  - 2023 Jul 24
TI  - Endothelial SARS-CoV-2 infection is not the underlying cause of 
      COVID19-associated vascular pathology in mice.
LID - 2023.07.24.550352 [pii]
LID - 10.1101/2023.07.24.550352 [doi]
AB  - Endothelial damage and vascular pathology have been recognized as major features 
      of COVID-19 since the beginning of the pandemic. Two main theories regarding how 
      Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) damages endothelial 
      cells and causes vascular pathology have been proposed: direct viral infection of 
      endothelial cells or indirect damage mediated by circulating inflammatory 
      molecules and immune mechanisms. However, these proposed mechanisms remain 
      largely untested in vivo. Here, we utilized a set of new mouse genetic tools (1) 
      developed in our lab to test both the necessity and sufficiency of endothelial 
      human angiotensin-converting enzyme 2 (hACE2) in COVID19 pathogenesis. Our 
      results demonstrate that endothelial ACE2 and direct infection of vascular 
      endothelial cells does not contribute significantly to the diverse vascular 
      pathology associated with COVID-19.
FAU - Gao, Siqi
AU  - Gao S
FAU - Tang, Alan T
AU  - Tang AT
FAU - Wang, Min
AU  - Wang M
FAU - Buchholz, David W
AU  - Buchholz DW
FAU - Imbiakha, Brian
AU  - Imbiakha B
FAU - Yang, Jisheng
AU  - Yang J
FAU - Chen, Xiaowen
AU  - Chen X
FAU - Hewins, Peter
AU  - Hewins P
FAU - Mericko-Ishizuka, Patricia
AU  - Mericko-Ishizuka P
FAU - Leu, N Adrian
AU  - Leu NA
FAU - Sterling, Stephanie
AU  - Sterling S
FAU - August, Avery
AU  - August A
FAU - Jurado, Kellie A
AU  - Jurado KA
FAU - Morrisey, Edward E
AU  - Morrisey EE
FAU - Aguilar-Carreno, Hector
AU  - Aguilar-Carreno H
FAU - Kahn, Mark L
AU  - Kahn ML
AUID- ORCID: 0000-0002-6489-7086
LA  - eng
PT  - Preprint
DEP - 20230724
PL  - United States
TA  - bioRxiv
JT  - bioRxiv : the preprint server for biology
JID - 101680187
UIN - Front Cardiovasc Med. 2023 Sep 26;10:1266276. PMID: 37823176
PMC - PMC10402014
EDAT- 2023/08/07 06:42
MHDA- 2023/08/07 06:43
PMCR- 2023/08/04
CRDT- 2023/08/07 04:45
PHST- 2023/08/07 06:43 [medline]
PHST- 2023/08/07 06:42 [pubmed]
PHST- 2023/08/07 04:45 [entrez]
PHST- 2023/08/04 00:00 [pmc-release]
AID - 2023.07.24.550352 [pii]
AID - 10.1101/2023.07.24.550352 [doi]
PST - epublish
SO  - bioRxiv [Preprint]. 2023 Jul 24:2023.07.24.550352. doi: 
      10.1101/2023.07.24.550352.