PMID- 37547430
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 0976-237X (Print)
IS  - 0976-2361 (Electronic)
IS  - 0976-2361 (Linking)
VI  - 14
IP  - 2
DP  - 2023 Apr-Jun
TI  - Association of Serum Interleukin-10 Level with Glycemic Status to Predict 
      Glycemic Alteration with Periodontitis: A Cross-Sectional, Observational Study.
PG  - 152-156
LID - 10.4103/ccd.ccd_537_22 [doi]
AB  - BACKGROUND AND AIM: Studies showed bidirectional relationship between chronic 
      periodontitis (CPD) and diabetes. This study was conducted to estimate the levels 
      of serum interleukin (IL)-10 in patients with CPD and type 2 diabetes mellitus 
      (T2DM) to evaluate the association of serum IL-10 levels with glycemic status and 
      to evaluate the influence of periodontal inflammation on glycemic control. 
      SETTING AND DESIGN: A cross-sectional observational study. MATERIALS AND METHODS: 
      Eighty patients were divided into four groups consisting of 20 patients in each 
      group. Group 1: healthy control, Group 2: T2DM without chronic periodontitis, 
      Group 3: chronic periodontitis only (CPD), and Group 4: T2DM with chronic 
      periodontitis (CPD). Plaque index, gingival index, pocket probing depth, clinical 
      attachment loss, random blood sugar, and glycated hemoglobin (HbA1c) level were 
      recorded for categorizing patients into aforestated groups. Serum IL-10 level was 
      measured by ELISA kit. STATISTICAL ANALYSIS USED: ANOVA statistics and post hoc 
      Tukey's test were performed for comparing individual groups. RESULTS: IL-10 was 
      detected lowest in Group 3 followed by Group 4. Highest level of IL-10 was found 
      in the healthy group then in Group 2. CONCLUSION: IL-10 levels have an inverse 
      relationship with HbA1c. Lowest level of IL-10 in CPD dictates periodontal 
      inflammation itself influences in regulating serum IL-10 level and poor glycemic 
      control. Serum IL-10 level may be one of the predictors of glycemia.
CI  - Copyright: (c) 2023 Contemporary Clinical Dentistry.
FAU - Ikbal, S K Aziz
AU  - Ikbal SKA
AD  - Department of Periodontology, Career PG Institute of Dental Sciences, Lucknow, 
      Uttar Pradesh, India.
FAU - Gupta, Sanjay
AU  - Gupta S
AD  - Department of Periodontology, Career PG Institute of Dental Sciences, Lucknow, 
      Uttar Pradesh, India.
FAU - Tiwari, Vandana
AU  - Tiwari V
AD  - Department of Biochemistry, Dr. RML Institute of Medical Sciences, Lucknow, Uttar 
      Pradesh, India.
FAU - Dhinsa, Gurpreet
AU  - Dhinsa G
AD  - Department of Periodontology, Career PG Institute of Dental Sciences, Lucknow, 
      Uttar Pradesh, India.
FAU - Verma, Neelu
AU  - Verma N
AD  - Department of Periodontology, Career PG Institute of Dental Sciences, Lucknow, 
      Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20230630
PL  - India
TA  - Contemp Clin Dent
JT  - Contemporary clinical dentistry
JID - 101552967
PMC - PMC10399803
OTO - NOTNLM
OT  - Chronic periodontitis
OT  - diabetes mellitus
OT  - glycated hemoglobin
OT  - interleukin-10
COIS- There are no conflicts of interest.
EDAT- 2023/08/07 06:42
MHDA- 2023/08/07 06:43
PMCR- 2023/04/01
CRDT- 2023/08/07 04:52
PHST- 2022/11/09 00:00 [received]
PHST- 2023/04/10 00:00 [revised]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/08/07 06:43 [medline]
PHST- 2023/08/07 06:42 [pubmed]
PHST- 2023/08/07 04:52 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - CCD-14-152 [pii]
AID - 10.4103/ccd.ccd_537_22 [doi]
PST - ppublish
SO  - Contemp Clin Dent. 2023 Apr-Jun;14(2):152-156. doi: 10.4103/ccd.ccd_537_22. Epub 
      2023 Jun 30.