PMID- 37548006
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20231101
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 63
IP  - 8
DP  - 2023 Sep
TI  - Altered resting-state effective connectivity of trigeminal vascular system in 
      migraine without aura: A spectral dynamic causal modeling study.
PG  - 1119-1127
LID - 10.1111/head.14602 [doi]
AB  - BACKGROUND: The trigeminal vascular system is an important part of the anatomical 
      and physiological basis of migraine. The effective connectivity (EC) among the 
      regions of interest (ROIs) in the trigeminal vascular system involved in migraine 
      without aura (MWoA) remains unclear. METHODS: In this cross-sectional study, 48 
      patients (mean [SD] age 38.06 [10.35] years; male, 14/48 [29%]) with MWoA during 
      the interictal phase and 48 healthy controls of similar age and sex (mean [SD] 
      age 38.96 [10.96] years; male, 14/48 [29%]) underwent resting-state functional 
      magnetic resonance imaging (fMRI). Dynamic causal modeling analysis was conducted 
      to investigate directional EC among ROIs in the trigeminal vascular system 
      including the bilateral brainstem, the primary somatosensory cortex (S1), the 
      thalamus, and the insula. RESULTS: Compared with the healthy control group, MWoA 
      represented significantly reduced EC from the left brainstem (Brainstem.L) to the 
      left insula (MWoA: mean [SD] -0.16 [0.36]; healthy controls: mean [SD] 
      0.11 [0.41]; P(corrected)  = 0.021), reduced EC from the Brainstem.L to the right 
      insula (MWoA: mean [SD] -0.15 [0.39]; healthy controls: mean [SD] 0.03 [0.35]; 
      P(corrected)  = 0.021), and decreased EC from the left thalamus (Thalamus.L) to 
      the Brainstem.L (MWoA: mean [SD] -0.13 [0.56]; healthy controls: mean [SD] 
      0.10 [0.45]; P(corrected)  = 0.021). Altered EC parameters were not significantly 
      correlated with MWoA clinical data. CONCLUSION: These results further provide 
      increasing evidence that disturbed homeostasis of the trigeminovascular 
      nociceptive pathway is involved in the pathophysiological mechanisms of migraine. 
      Patients with MWoA exhibited a regional interaction distinct from healthy 
      controls in the neural pathway of the Bilateral Insula-Brainstem.L-Thalamus.L, 
      which may shed light on the future understanding of brain mechanisms for MWoA. 
      Future brain-based interventions are suggested to consider the dysregulation in 
      the Bilateral Insula-Brainstem.L-Thalamus.L circuits.
CI  - (c) 2023 American Headache Society.
FAU - Qin, Zhaoxia
AU  - Qin Z
AD  - Department of Radiology, Medical Imaging Center, The Affiliated Hospital of 
      Yangzhou University, Yangzhou University, Yangzhou, China.
FAU - Qu, Hang
AU  - Qu H
AD  - Department of Radiology, Medical Imaging Center, The Affiliated Hospital of 
      Yangzhou University, Yangzhou University, Yangzhou, China.
FAU - Liang, Huai-Bin
AU  - Liang HB
AD  - Department of Neurology, Jiuyuan Municipal Stroke Center, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
AD  - Clinical Research Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Zhou, Qichen
AU  - Zhou Q
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Radiology, Medical Imaging Center, The Affiliated Hospital of 
      Yangzhou University, Yangzhou University, Yangzhou, China.
FAU - Wang, Min
AU  - Wang M
AD  - School of Humanities and Social Science, University of Science and Technology of 
      China, Hefei, China.
FAU - Liu, Jian-Ren
AU  - Liu JR
AD  - Department of Neurology, Jiuyuan Municipal Stroke Center, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
AD  - Clinical Research Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Du, Xiaoxia
AU  - Du X
AUID- ORCID: 0000-0001-8470-7852
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
LA  - eng
GR  - 81571658/National Natural Science Foundation of China/
GR  - 20161422/Shanghai Municipal Education Commission/
GR  - 22ZR1436900/Shanghai Municipal Science and Technology Commission/
PT  - Journal Article
DEP - 20230807
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - *Migraine without Aura/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Magnetic Resonance Imaging/methods
MH  - Brain
MH  - Brain Stem/diagnostic imaging
OTO - NOTNLM
OT  - dynamic causal modeling
OT  - effective connectivity
OT  - functional MRI
OT  - migraine
OT  - trigeminal vascular system
EDAT- 2023/08/07 06:41
MHDA- 2023/09/20 06:42
CRDT- 2023/08/07 05:25
PHST- 2023/05/29 00:00 [revised]
PHST- 2022/10/28 00:00 [received]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/08/07 06:41 [pubmed]
PHST- 2023/08/07 05:25 [entrez]
AID - 10.1111/head.14602 [doi]
PST - ppublish
SO  - Headache. 2023 Sep;63(8):1119-1127. doi: 10.1111/head.14602. Epub 2023 Aug 7.