PMID- 37548871
OWN - NLM
STAT- MEDLINE
DCOM- 20240419
LR  - 20240419
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1450
DP  - 2024
TI  - Systemic Inflammation but not Oxidative Stress Is Associated with Physical 
      Performance in Moderate Chronic Obstructive Pulmonary Disease.
PG  - 121-130
LID - 10.1007/5584_2023_784 [doi]
AB  - Chronic obstructive pulmonary disease (COPD) patients manifest muscle dysfunction 
      and impaired muscle oxidative capacity, which result in reduced exercise capacity 
      and poor health status. The aim of this study was to compare the physical 
      performance, systemic inflammation, and oxidative stress of patients with 
      moderate COPD, and to associate physical performance with inflammatory and 
      oxidative stress plasma markers. Twenty CONTROL (n = 10) and moderate COPD 
      (n = 10) patients participated in this study. Systematic inflammation and 
      oxidative stress plasma markers, maximal aerobic capacity (VO(2peak)), and 
      maximal isometric strength (MVIC) of the knee extensor (KE) muscles were 
      measured. VO(2peak) was 31.3% greater in CONTROL compared to COPD (P = 0.006). 
      The MVIC strength of the KE was 43.9% greater in CONTROL compared to COPD 
      (P = 0.002). Tumor necrosis factor-alpha (TNF-alpha) was 79.6% greater in COPD 
      compared to CONTROL (P < 0.001). Glutathione peroxidase activity (GPx) activity 
      was 27.5% lesser in COPD compared to CONTROL (P = 0.05). TNF-alpha concentration was 
      correlated with KE MVC strength (R = -0.48; P = 0.045) and VO(2peak) (R = -0.58; 
      P = 0.01). Meanwhile, malondialdehyde (MDA) and GPx activity were not associated 
      with KE strength or VO(2peak) (P = 0.74 and P = 0.14, respectively). COPD 
      patients showed lesser muscle strength and aerobic capacity than healthy control 
      individuals. Furthermore, patients with COPD showed greater systemic inflammation 
      and lesser antioxidant capacity than healthy counterparts. A moderate association 
      was evident between levels of systemic inflammation and physical performance 
      variables.
CI  - (c) 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
FAU - Penailillo, Luis
AU  - Penailillo L
AD  - Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, 
      Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile.
FAU - Miranda-Fuentes, Claudia
AU  - Miranda-Fuentes C
AD  - Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, 
      Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile.
FAU - Gutierrez, Sebastian
AU  - Gutierrez S
AD  - Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, 
      Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile.
FAU - Garcia-Vicencio, Sebastian
AU  - Garcia-Vicencio S
AD  - LBEPS, Univ Evry, IRBA, Universite Paris Saclay, Evry, France.
AD  - Human Motion Analysis, Humanfab, Aix-en-Provence, France.
FAU - Jannas-Vela, Sebastian
AU  - Jannas-Vela S
AD  - Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.
FAU - Acevedo, Cristian Campos
AU  - Acevedo CC
AD  - Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, 
      Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile.
FAU - Penailillo, Reyna S
AU  - Penailillo RS
AD  - Laboratory of Reproductive Biology, Faculty of Medicine, Centre for Biomedical 
      Research, Universidad de Los Andes, Santiago, Chile. rpenailillo@uandes.cl.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - *Tumor Necrosis Factor-alpha
MH  - Oxidative Stress/physiology
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Antioxidants/metabolism
MH  - Inflammation
MH  - Physical Functional Performance
OTO - NOTNLM
OT  - COPD
OT  - Pulmonary rehabilitation
OT  - Respiratory
OT  - TNF-alpha
EDAT- 2023/08/07 13:10
MHDA- 2024/04/19 06:43
CRDT- 2023/08/07 11:13
PHST- 2024/04/19 06:43 [medline]
PHST- 2023/08/07 13:10 [pubmed]
PHST- 2023/08/07 11:13 [entrez]
AID - 10.1007/5584_2023_784 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2024;1450:121-130. doi: 10.1007/5584_2023_784.