PMID- 37553950
OWN - NLM
STAT- MEDLINE
DCOM- 20231010
LR  - 20231010
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 37
IP  - 6
DP  - 2023 Nov
TI  - Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the 
      Risk of Developing Allergic Rhinitis and the Response to Intranasal 
      Corticosteroids in a Chinese Han Population.
PG  - 751-757
LID - 10.1177/19458924231193156 [doi]
AB  - BACKGROUND: Evidence has shown that glucocorticoid-induced transcript 1 (GLCCI1) 
      single nucleotide polymorphism (SNP) rs37937 is associated with asthma. 
      OBJECTIVES: The objective of this study was to investigate whether the GLCCI1 SNP 
      rs37937 is a risk factor for allergic rhinitis (AR) in a Chinese Han population. 
      METHODS: A total of 220 individuals including 109 AR patients and 111 healthy 
      subjects were included. The genotyping of GLCCI1 rs37973 was performed by the 
      SNaPshot method. The correlations of rs37973 polymorphism, AR risk, and clinical 
      characteristics were further analyzed, as well as the treatment response to 
      intranasal corticosteroids (INCS) in AR patients of different genotypes. RESULTS: 
      Three GLCCI1 rs37973 SNP genotypes were identified in both AR patients and 
      healthy subjects. Significant association between rs37973 polymorphism and AR 
      under allele model, dominant model, heterozygote model, and homozygote model were 
      shown. The A allele frequency of SNP rs37973 in AR was significantly higher than 
      that in controls. The serum total immunoglobulin E (IgE) in AR patients of AA 
      genotype was significantly higher than in patients of GA and GG genotype, and the 
      serum total IgE in GA genotype was significantly higher than in GG genotype. 
      Interestingly, after 4 weeks of INCS treatment for AR patients, the improvement 
      of the nasal itching score, sneezing score, runny nose score, total nasal symptom 
      score, and visual analog scale score of the GG genotype were worse than the AA or 
      GA genotype. CONCLUSION: The GLCCI1 rs37937 polymorphism is associated with the 
      risk of developing AR and the response to INCS treatment in the Chinese Han 
      population.
FAU - Liang, Xu
AU  - Liang X
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      China. RINGGOLD: 531675
FAU - Jin, Peng
AU  - Jin P
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      China. RINGGOLD: 531675
FAU - Zhan, Changcui
AU  - Zhan C
AD  - Department of Otolaryngology, Dongping County People's Hospital, Taian, China.
FAU - Zhao, Li
AU  - Zhao L
AUID- ORCID: 0000-0003-1777-0493
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      China. RINGGOLD: 531675
FAU - Zi, Xiaoxue
AU  - Zi X
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      China. RINGGOLD: 531675
FAU - Zhi, Lili
AU  - Zhi L
AD  - Department of Allergy, Shandong Provincial Qianfoshan Hospital, The First 
      Affiliated Hospital of Shandong First Medical University, Shandong Institute of 
      Respiratory Diseases, Jinan, China. RINGGOLD: 66310. RINGGOLD: 66310
FAU - Yu, Kena
AU  - Yu K
AUID- ORCID: 0000-0003-1638-7468
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      China. RINGGOLD: 531675
LA  - eng
PT  - Journal Article
DEP - 20230808
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Glucocorticoids)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (GLCCI1 protein, human)
RN  - Han Chinese people
SB  - IM
MH  - Humans
MH  - East Asian People
MH  - Genotype
MH  - *Glucocorticoids/administration & dosage/therapeutic use
MH  - Immunoglobulin E/genetics/immunology
MH  - Polymorphism, Single Nucleotide
MH  - *Receptors, Glucocorticoid/genetics
MH  - *Rhinitis, Allergic/drug therapy/genetics/immunology
MH  - Administration, Intranasal
MH  - Risk Factors
OTO - NOTNLM
OT  - Chinese Han population
OT  - GLCCI1
OT  - IgE
OT  - allele
OT  - allergic rhinitis
OT  - clinical characteristics
OT  - gene
OT  - genotype
OT  - intranasal corticosteroids
OT  - single nucleotide polymorphism
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/08/09 06:43
MHDA- 2023/10/04 06:43
CRDT- 2023/08/09 02:33
PHST- 2023/10/04 06:43 [medline]
PHST- 2023/08/09 06:43 [pubmed]
PHST- 2023/08/09 02:33 [entrez]
AID - 10.1177/19458924231193156 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2023 Nov;37(6):751-757. doi: 10.1177/19458924231193156. Epub 
      2023 Aug 8.