PMID- 37554106
OWN - NLM
STAT- MEDLINE
DCOM- 20230823
LR  - 20230828
IS  - 1750-192X (Electronic)
IS  - 1750-192X (Linking)
VI  - 15
IP  - 11
DP  - 2023 Jun
TI  - Exploring the molecular targets for Type 2 diabetes-induced Alzheimer's disease 
      through bioinformatics analysis.
PG  - 619-633
LID - 10.2217/epi-2023-0149 [doi]
AB  - Aim: The purpose of this study was to elucidate the potential mechanisms of 
      Alzheimer's disease (AD) induced by Type 2 diabetes mellitus (T2DM) through 
      bioinformatics analysis, to provide new treatment targets for this disease. 
      Methods: We used weighted gene coexpression network analysis and differentially 
      expressed genes analysis to identify significantly differentially expressed genes 
      shared by T2DM and AD. Molecular docking was used to predict possible protein 
      targets for T2DM-induced AD. Results: The direct interaction of CD44 and STAT3 
      may play a significant role in the development of T2DM-induced AD. Conclusion: A 
      new approach to treating T2DM-associated AD may be provided by these hub genes 
      and their predicted molecular targets.
FAU - Gao, Lin
AU  - Gao L
AD  - The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
FAU - Huang, Chengyu
AU  - Huang C
AD  - The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
FAU - Li, Hui
AU  - Li H
AD  - The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
FAU - Wu, Shidi
AU  - Wu S
AD  - The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
FAU - Zhou, Xiaoyan
AU  - Zhou X
AD  - Xuzhou Engineering Research Center of Medical Genetics & Transformation, 
      Department of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China.
FAU - Ying, Changjiang
AU  - Ying C
AD  - Xuzhou Engineering Research Center of Medical Genetics & Transformation, 
      Department of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China.
AD  - Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, 221002, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230809
PL  - England
TA  - Epigenomics
JT  - Epigenomics
JID - 101519720
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *Alzheimer Disease/genetics/metabolism
MH  - Molecular Docking Simulation
MH  - Gene Regulatory Networks
MH  - Computational Biology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - CD44
OT  - STAT3
OT  - Type 2 diabetes mellitus
OT  - bioinformatics analysis
EDAT- 2023/08/09 06:43
MHDA- 2023/08/23 06:42
CRDT- 2023/08/09 03:53
PHST- 2023/08/23 06:42 [medline]
PHST- 2023/08/09 06:43 [pubmed]
PHST- 2023/08/09 03:53 [entrez]
AID - 10.2217/epi-2023-0149 [doi]
PST - ppublish
SO  - Epigenomics. 2023 Jun;15(11):619-633. doi: 10.2217/epi-2023-0149. Epub 2023 Aug 
      9.