PMID- 37554469
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230810
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 8
DP  - 2023 Aug 18
TI  - Adverse effect propensity: A new feature of Gulf War illness predicted by 
      environmental exposures.
PG  - 107363
LID - 10.1016/j.isci.2023.107363 [doi]
LID - 107363
AB  - A third of 1990-1 Gulf-deployed personnel developed drug/chemical-induced 
      multisymptom illness, "Gulf War illness" (GWI). Veterans with GWI (VGWI) report 
      increased drug/exposure adverse effects (AEs). Using previously collected data 
      from a case-control study, we evaluated whether the fraction of exposures that 
      engendered AEs ("AE Propensity") is increased in VGWI (it was); whether AE 
      Propensity is related to self-rated "chemical sensitivity" (it did); and whether 
      specific exposures "predicted" AE Propensity (they did). Pesticides and radiation 
      exposure were significant predictors, with copper significantly "protective"-in 
      the total sample (adjusted for GWI-status) and separately in VGWI and controls, 
      on multivariable regression. Mitochondrial impairment and oxidative stress (OS) 
      underlie AEs from many exposures irrespective of nominal specific mechanism. We 
      hypothesize that mitochondrial toxicity and interrelated OS from pesticides and 
      radiation position people on the steep part of the curve of mitochondrial 
      impairment and OS versus symptom/biological disruption, amplifying impact of new 
      exposures. Copper, meanwhile, is involved in critical OS detoxification 
      processes.
CI  - (c) 2023 The Author(s).
FAU - Golomb, Beatrice A
AU  - Golomb BA
AD  - Department of Medicine, University of California, San Diego, La Jolla, CA 92093, 
      USA.
FAU - Han, Jun Hee
AU  - Han JH
AD  - Department of Medicine, University of California, San Diego, La Jolla, CA 92093, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20230713
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC10405325
OTO - NOTNLM
OT  - Environmental chemistry
OT  - Environmental health
OT  - Environmental toxicology
OT  - Health sciences
COIS- The authors declare no competing interests.
EDAT- 2023/08/09 06:44
MHDA- 2023/08/09 06:45
PMCR- 2023/07/13
CRDT- 2023/08/09 04:00
PHST- 2022/08/29 00:00 [received]
PHST- 2023/05/26 00:00 [revised]
PHST- 2023/07/10 00:00 [accepted]
PHST- 2023/08/09 06:45 [medline]
PHST- 2023/08/09 06:44 [pubmed]
PHST- 2023/08/09 04:00 [entrez]
PHST- 2023/07/13 00:00 [pmc-release]
AID - S2589-0042(23)01440-2 [pii]
AID - 107363 [pii]
AID - 10.1016/j.isci.2023.107363 [doi]
PST - epublish
SO  - iScience. 2023 Jul 13;26(8):107363. doi: 10.1016/j.isci.2023.107363. eCollection 
      2023 Aug 18.