PMID- 37554584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230810
IS  - 1179-7282 (Electronic)
IS  - 1179-7282 (Linking)
VI  - 14
DP  - 2023
TI  - Insights into Magnetic Resonance Imaging Findings in Central Nervous System 
      Paracoccidioidomycosis: A Comprehensive Review.
PG  - 87-98
LID - 10.2147/RRTM.S391633 [doi]
AB  - Paracoccidioidomycosis (PCM) is a infection caused by the thermodimorphic fungus 
      Paracoccidioides spp. (P. lutzii and, mainly, P. brasiliensis). This infection 
      predominantly affects rural male workers aged between 30 and 50 years old who 
      deal with soil on daily activities. Clinically, the disease is classified as 
      acute/subacute phase, which evolves rapidly, secondary to dissemination of the 
      fungus through to the phagocytic-mononuclear system, leading to fever, weight 
      loss, and anorexia, associated with hepatosplenomegaly and lymphadenopathy, which 
      can be complicated with suppuration and fistulization; and chronic phase, which 
      corresponds to 74% to 95% of symptomatic cases, with a common pulmonary 
      involvement. Central nervous system involvement is almost always a characteristic 
      of the chronic form. Inhalation is the most common route of primary infection, 
      usually affecting the lungs, forming the primary complex. From the primary 
      complex, hematogenic dissemination can occur to any organ, including the brain 
      and spinal cord. Although PCM of the central nervous system diagnosis is usually 
      based on histopathological analysis and the imaging features are not specific for 
      PCM, computed tomography and magnetic resonance imaging can demonstrate evidences 
      of granuloma, abscess, meningitis, or a combination of these lesions, 
      contributing to a preoperative diagnosis, especially when considered in 
      conjunction with epidemiology. In this article, we review the pathophysiology, 
      clinical manifestations and imaging aspects of neuro-PCM.
CI  - (c) 2023 Costa et al.
FAU - Costa, Rangel de Sousa
AU  - Costa RS
AUID- ORCID: 0000-0001-8710-5486
AD  - Department of Radiology, Paulo Niemeyer State Brain Institute, Rio de Janeiro, 
      RJ, Brazil.
FAU - Hygino da Cruz, Luiz Celso Jr
AU  - Hygino da Cruz LC Jr
AD  - Department of Radiology, Clinica de Diagnostico por Imagem (CDPI)/DASA, Rio de 
      Janeiro, RJ, Brazil.
FAU - de Souza, Simone Rachid
AU  - de Souza SR
AD  - Department of Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
FAU - Ventura, Nina
AU  - Ventura N
AD  - Department of Radiology, Paulo Niemeyer State Brain Institute, Rio de Janeiro, 
      RJ, Brazil.
FAU - Correa, Diogo Goulart
AU  - Correa DG
AUID- ORCID: 0000-0003-4902-0021
AD  - Department of Radiology, Clinica de Diagnostico por Imagem (CDPI)/DASA, Rio de 
      Janeiro, RJ, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230803
PL  - New Zealand
TA  - Res Rep Trop Med
JT  - Research and reports in tropical medicine
JID - 101562656
PMC - PMC10406117
OTO - NOTNLM
OT  - granuloma
OT  - magnetic resonance imaging
OT  - meningitis
OT  - neuro-PCM
OT  - paracoccidioidomycosis
COIS- The authors report no conflicts of interest in this work.
EDAT- 2023/08/09 06:43
MHDA- 2023/08/09 06:44
PMCR- 2023/08/03
CRDT- 2023/08/09 04:03
PHST- 2023/04/19 00:00 [received]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2023/08/09 06:44 [medline]
PHST- 2023/08/09 06:43 [pubmed]
PHST- 2023/08/09 04:03 [entrez]
PHST- 2023/08/03 00:00 [pmc-release]
AID - 391633 [pii]
AID - 10.2147/RRTM.S391633 [doi]
PST - epublish
SO  - Res Rep Trop Med. 2023 Aug 3;14:87-98. doi: 10.2147/RRTM.S391633. eCollection 
      2023.