PMID- 37555104
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230810
IS  - 1948-9366 (Print)
IS  - 1948-9366 (Electronic)
VI  - 15
IP  - 7
DP  - 2023 Jul 27
TI  - Idiopathic hypereosinophilic syndrome with hepatic sinusoidal obstruction 
      syndrome: A case report and literature review.
PG  - 1532-1541
LID - 10.4240/wjgs.v15.i7.1532 [doi]
AB  - BACKGROUND: Hypereosinophilic syndrome (HES) is classified as primary, secondary 
      or idiopathic. Idiopathic HES (IHES) has a variable clinical presentation and may 
      involve multiple organs causing severe damage. Hepatic sinusoidal obstruction 
      syndrome (HSOS) is characterized by damage to the endothelial cells of the 
      hepatic sinusoids of the hepatic venules, with occlusion of the hepatic venules, 
      and hepatocyte necrosis. We report a case of IHES with HSOS of uncertain 
      etiology. CASE SUMMARY: A 70-year-old male patient was admitted to our hospital 
      with pruritus and a rash on the extremities for > 5 mo. He had previously 
      undergone antiallergic treatment and herbal therapy in the local hospital, but 
      the symptoms recurred. Relevant examinations were completed after admission. Bone 
      marrow aspiration biopsy showed a significantly higher percentage of eosinophils 
      (23%) with approximately normal morphology. Ultrasound-guided hepatic aspiration 
      biopsy indicated HSOS. Contrast-enhanced computed tomography (CT) of the upper 
      abdomen showed hepatic venule congestion with hydrothorax and ascites. The 
      patient was initially diagnosed with IHES and hepatic venule occlusion. 
      Prednisone, low molecular weight heparin and ursodeoxycholic acid were given for 
      treatment, followed by discontinuation of low molecular weight heparin due to 
      ecchymosis. Routine blood tests, biochemical tests, and imaging such as enhanced 
      CT of the upper abdomen and pelvis were reviewed regularly. CONCLUSION: 
      Hypereosinophilia may play a facilitating role in the occurrence and development 
      of HSOS.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xu, Xu-Tao
AU  - Xu XT
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Wang, Bing-Hong
AU  - Wang BH
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - Department of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery, 
      Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310014, 
      Zhejiang Province, China.
FAU - Guo, Yang-Jie
AU  - Guo YJ
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Zhang, Yu-Ning
AU  - Zhang YN
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Chen, Xiao-Li
AU  - Chen XL
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Fang, Yan-Fei
AU  - Fang YF
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Wang, Kan
AU  - Wang K
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
FAU - Guo, Wen-Hao
AU  - Guo WH
AD  - Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang 
      University, Hangzhou 310016, Zhejiang Province, China.
FAU - Wen, Zhen-Zhen
AU  - Wen ZZ
AD  - Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou 310016, Zhejiang Province, China. 
      3315019@zju.edu.cn.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Gastrointest Surg
JT  - World journal of gastrointestinal surgery
JID - 101532473
PMC - PMC10405125
OTO - NOTNLM
OT  - Bone marrow aspiration biopsy
OT  - Case report
OT  - Hepatic aspiration biopsy
OT  - Hepatic sinusoidal obstruction syndrome
OT  - Hypereosinophilic syndrome
OT  - Prednisone
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/08/09 06:43
MHDA- 2023/08/09 06:44
PMCR- 2023/07/27
CRDT- 2023/08/09 04:10
PHST- 2023/03/08 00:00 [received]
PHST- 2023/04/17 00:00 [revised]
PHST- 2023/05/17 00:00 [accepted]
PHST- 2023/08/09 06:44 [medline]
PHST- 2023/08/09 06:43 [pubmed]
PHST- 2023/08/09 04:10 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - 10.4240/wjgs.v15.i7.1532 [doi]
PST - ppublish
SO  - World J Gastrointest Surg. 2023 Jul 27;15(7):1532-1541. doi: 
      10.4240/wjgs.v15.i7.1532.