PMID- 3755703
OWN - NLM
STAT- MEDLINE
DCOM- 19861015
LR  - 20190908
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 8
IP  - 4
DP  - 1986
TI  - Broncho-Vaxom and spontaneous allergic autocytotoxicity (spACT) in bronchial 
      asthma associated with food hypersensitivity.
PG  - 433-6
AB  - Spontaneous allergic autocytotoxicity (spACT) of white blood cells (WBC) was 
      assessed in six bronchial asthma patients and eighteen normal control 
      individuals. The observed alterations of non-primed WBC membrane were revealed as 
      an increased uptake of trypan blue exclusion dye, an indicator of death cells. 
      The phenomenon of spACT might be associated with a lack of T suppressor cell 
      intervention, increased refractoriness of WBC membrane leading to its increased 
      permeability and enhanced releasability of chemical mediators of anaphylaxis, 
      which probably bypasses IgE events. In six bronchial asthma patients, three were 
      sensitive toward wheat, two had cow milk sensitivity, and one had corn 
      sensitivity. When WBC of these patients were studied in the direct ACT assay, an 
      additional augmentation of spACT effect by specific food antigens was observed. 
      Surprisingly, Broncho-Vaxom (BX) did not inhibit or enhance spACT. However, BX 
      has antagonistic activity toward direct ACT response in the dose-dependent 
      concentration as previously reported. Our preliminary clinical experience leads 
      us to believe that the spACT assay can serve as a useful clinical discriminator 
      of potential responders versus non-responders to therapy with new agents, when 
      WBC disintegration by autoinduction is involved.
FAU - Podleski, W K
AU  - Podleski WK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Broncho-Vaxom)
RN  - 0 (Cell Extracts)
SB  - IM
MH  - *Adjuvants, Immunologic
MH  - Asthma/etiology/*immunology
MH  - *Bacteria
MH  - *Cell Extracts
MH  - *Cytotoxicity, Immunologic
MH  - Food Hypersensitivity/complications/*immunology
MH  - Humans
MH  - Leukocytes/drug effects/*immunology
MH  - Reference Values
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 0192-0561(86)90128-1 [pii]
AID - 10.1016/0192-0561(86)90128-1 [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 1986;8(4):433-6. doi: 10.1016/0192-0561(86)90128-1.