PMID- 37557075
OWN - NLM
STAT- MEDLINE
DCOM- 20230811
LR  - 20230811
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 56
IP  - 8
DP  - 2023 Aug 8
TI  - Resident dendritic cell density in the lymph node paracortex is preDC-estined.
PG  - 1699-1701
LID - S1074-7613(23)00326-6 [pii]
LID - 10.1016/j.immuni.2023.07.013 [doi]
AB  - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph 
      nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 
      conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node 
      from a supply of preDCs that proliferate in nearby medullary vessels. Transition 
      from preDC to cDC1 is regulated by Flt3L sensing.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Czepielewski, Rafael S
AU  - Czepielewski RS
AD  - Immunology Center of Georgia, Medical College of Georgia, Department of 
      Physiology, Augusta University, Augusta, GA, USA.
FAU - Randolph, Gwendalyn J
AU  - Randolph GJ
AD  - Department of Pathology, Washington University School of Medicine, St. Louis, MO, 
      USA. Electronic address: gjrandolph@wustl.edu.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
SB  - IM
CON - Immunity. 2023 Aug 8;56(8):1778-1793.e10. PMID: 37463581
MH  - *Lymphoid Tissue
MH  - *Lymph Nodes
MH  - Dendritic Cells
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2023/08/10 00:42
MHDA- 2023/08/11 06:42
CRDT- 2023/08/09 18:18
PHST- 2023/07/16 00:00 [received]
PHST- 2023/07/17 00:00 [revised]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/08/11 06:42 [medline]
PHST- 2023/08/10 00:42 [pubmed]
PHST- 2023/08/09 18:18 [entrez]
AID - S1074-7613(23)00326-6 [pii]
AID - 10.1016/j.immuni.2023.07.013 [doi]
PST - ppublish
SO  - Immunity. 2023 Aug 8;56(8):1699-1701. doi: 10.1016/j.immuni.2023.07.013.