PMID- 37559223
OWN - NLM
STAT- Publisher
LR  - 20230810
IS  - 2211-9132 (Print)
IS  - 2211-9132 (Linking)
DP  - 2023 Aug 10
TI  - Intrinsic prefrontal functional connectivity according to cognitive impairment in 
      patients with end-stage renal disease.
LID - 10.23876/j.krcp.22.291 [doi]
AB  - BACKGROUND: This study aimed to investigate differences in intrinsic prefrontal 
      functional connectivity according to the presence of cognitive impairment in 
      patients with end-stage renal disease (ESRD) using functional near-infrared 
      spectroscopy (fNIRS). METHODS: We prospectively enrolled 37 patients with ESRD 
      who had been undergoing hemodialysis for more than 6 months and had no history of 
      neurological or psychiatric disorders. All patients with ESRD underwent the 
      Korean version of the Montreal Cognitive Assessment (MoCA-K) to assess cognitive 
      function. The NIRSIT Lite device (OBELAB Inc.) was used to acquire fNIRS data, 
      and the NIRSIT Lite Analysis Tool program was used to process the data and 
      generate a functional connectivity matrix. We obtained functional connectivity 
      measures by applying graph theory to the connectivity matrix using the BRAPH 
      (brain analysis using graph theory) program. RESULTS: Of the 37 patients with 
      ESRD, 23 had cognitive impairment, whereas 14 patients showed no cognitive 
      impairment. Intrinsic prefrontal functional connectivity was significantly 
      different between groups. Network measures of strength, global efficiency, and 
      mean clustering coefficient were lower in ESRD patients with cognitive impairment 
      than in those without cognitive impairment (4.458 vs. 5.129, p = 0.02; 0.397 vs. 
      0.437, p = 0.03; and 0.316 vs. 0.421, p = 0.003; respectively). There were no 
      significant correlations between MoCA-K scores and clinical characteristics. 
      CONCLUSION: We demonstrated a significant association between cognitive function 
      and intrinsic prefrontal functional connectivity in patients with ESRD. ESRD 
      patients with cognitive impairment have reduced connectivity and segregation in 
      the prefrontal brain network compared to those without cognitive impairment.
FAU - Park, Kang Min
AU  - Park KM
AD  - Department of Neurology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Heo, Chang Min
AU  - Heo CM
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Lee, Dong Ah
AU  - Lee DA
AD  - Department of Neurology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Huh, Hyuk
AU  - Huh H
AD  - Department of Internal Medicine, Busan Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Park, Sihyung
AU  - Park S
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Kim, Yang Wook
AU  - Kim YW
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Lee, Yoo Jin
AU  - Lee YJ
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Yoon, Hyeok Jin
AU  - Yoon HJ
AD  - YOON's Clinic of Hemodialysis, Busan, Republic of Korea.
FAU - Park, Bong Soo
AU  - Park BS
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230810
PL  - Korea (South)
TA  - Kidney Res Clin Pract
JT  - Kidney research and clinical practice
JID - 101586778
OTO - NOTNLM
OT  - Chronic kidney failure
OT  - Cognition
OT  - Connectome
OT  - Frontal lobe
EDAT- 2023/08/10 06:43
MHDA- 2023/08/10 06:43
CRDT- 2023/08/10 00:34
PHST- 2022/12/20 00:00 [received]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/08/10 06:43 [medline]
PHST- 2023/08/10 06:43 [pubmed]
PHST- 2023/08/10 00:34 [entrez]
AID - j.krcp.22.291 [pii]
AID - 10.23876/j.krcp.22.291 [doi]
PST - aheadofprint
SO  - Kidney Res Clin Pract. 2023 Aug 10. doi: 10.23876/j.krcp.22.291.